ReviewBiomedicines2019
Graft Materials and Biologics for Spinal Interbody Fusion.
Review in Biomedicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07217964 (Evaluating Natural Matrix Protein), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Natural Matrix Protein (NMP) in Lumbar Spinal Fusion
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Stand-alone versus supplemented ALIF: a systematic review and meta-analysis of pseudarthrosis and reoperation rates.Neurosurgical review · 2026Pooled it
- A systematic review and meta-analysis of fusion rate enhancements and bone graft options for spine surgery.Scientific reports · 2022Pooled it
- 45S5 bioglass graft decreases surgical site infection after posterior transforaminal lumbar interbody fusion reconstruction compared to alternative graft materials.Journal of spine surgery (Hong Kong) · 2026Article
- Nonunion After Ankle Arthrodesis: A Contemporary Review.Foot & ankle international · 2026Review
- Real-world outcomes of minimally invasive posterior thoracic and lumbar spine fusion surgery versus open surgery in the Finnish Spine Registry.Journal of spine surgery (Hong Kong) · 2026Article
- Practical Strategies for Bone Graft Selection in Spinal Fusion: A Narrative Review with Regional Perspectives.Spine surgery and related research · 2026Review
- Design of 3D-printed hydroxyapatite intervertebral fusion cages in a patient specific framework.Medical & biological engineering & computing · 2026Article
- Thoracic corpectomy and vertebral body reconstruction (TCVBR): a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Imaging evidence of osseous fusion of patients undergoing segmental mandibular fibular free flap reconstruction - a retrospective analysis.Journal of clinical imaging science · 2026Article
- Preclinical evaluation of lateral interbody fusions using 3D printed PEEK or 3D printed titanium cages.North American Spine Society journal · 2025Article
- Transforming spinal surgery with innovations in biologics and additive manufacturing.Materials today. Bio · 2025Review
- Bone fusion materials: past, present, and future.Asian spine journal · 2025Article
- A safe and reproducible anterior column restoration technique for Kümmell's disease: transpedicular bone packing.Journal of spine surgery (Hong Kong) · 2025Article
- Efficacy of Stand-Alone Anterior Lumbar Interbody Fusion With PEEK Cages, BMP-2, and Allografts for Treating Discogenic Low Back Pain: Assessing Clinical and Radiographic Outcomes.International journal of spine surgery · 2024Article
- Clinical Implementation of Tissue-Sparing Posterior Cervical Fusion: Addressing Market Access Challenges.Journal of personalized medicine · 2024Article
- 3D-Printed Demineralized Bone Matrix-Based Conductive Scaffolds Combined with Electrical Stimulation for Bone Tissue Engineering Applications.ACS applied bio materials · 2024Article
- The Categorization of Perinatal Derivatives for Orthopedic Applications.Biomedicines · 2024Review
- Novel Approach to Difficult Spinal Reconstruction: Bilateral Simultaneous Rib and Iliac Crest Vascularized Bone Graft Spinoplastic Surgery.Plastic and reconstructive surgery. Global open · 2024Article
- Budget Impact Analysis of Minimally Invasive versus Open Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Disease: A European Hospital Perspective.ClinicoEconomics and outcomes research : CEOR · 2024Article
- Bone Grafting Options for Single-Level TLIF: So Many Options, What Is the Evidence?International journal of spine surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal fusion is the most widely performed procedure in spine surgery. It is the preferred treatment for a wide variety of pathologies including degenerative disc disease, spondylolisthesis, segmental instability, and deformity. Surgeons have the choice of fusing vertebrae by utilizing cages containing autografts, allografts, demineralized bone matrices (DBMs), or graft substitutes such as ceramic scaffolds. Autografts from the iliac spine are the most commonly used as they offer osteogenic, osteoinductive, and osteoconductive capabilities, all while avoiding immune system rejection. Allografts obtained from cadavers and living donors can also be advantageous as they lack the need for graft extraction from the patient. DBMs are acid-extracted organic allografts with osteoinductive properties. Ceramic grafts containing hydroxyapatite can be readily manufactured and are able to provide osteoinductive support while having a long shelf life. Further, bone-morphogenetic proteins (BMPs), mesenchymal stem cells (MSCs), synthetic peptides, and autologous growth factors are currently being optimized to assist in improving vertebral fusion. Genetic therapies utilizing viral transduction are also currently being devised. This review provides an overview of the advantages, disadvantages, and future directions of currently available graft materials. The current literature on growth factors, stem cells, and genetic therapy is also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.