Evidence map›Paper›PMID 31561480›Full record

ArticleBrain sciences2019

Endocannabinoids and Fear-Related Behavior in Mice Selectively Bred for High or Low Alcohol Preference.

Aaron M Kirchhoff, Eric L Barker, Julia A Chester

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Aaron M KirchhoffDepartment of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA. akirchho@scripps.edu.
Eric L BarkerDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. barkerel@purdue.edu.
Julia A ChesterDepartment of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA. jcheste@purdue.edu.
Purdue University West Lafayette · US

Funding

Anxiety in a genetic animal model of alcoholism: role of endocannabinoidsR21AA019529 · NIAAA · PURDUE UNIVERSITY · PI BARKER, ERIC L, CHESTER, JULIA ANN · 2010 to 2011
$411k
NIAAA NIH HHS AA019529
6 · The paper itself

Abstract

Alcohol use disorders (AUDs) have a high incidence of co-morbidity with stress-related psychopathologies, such as post-traumatic stress disorder (PTSD). Genetic and pharmacological studies support a prominent role for the endocannabinoid system (ECS) in modulating stress-related behaviors relevant to AUDs and PTSD. Mouse lines selectively bred for high (HAP) and low (LAP) alcohol preference show reproducible differences in fear-potentiated startle (FPS), a model for PTSD-related behavior. The first experiment in this study assessed levels of the endocannabinoids, anandamide (AEA) and

Indexed as

alcohol preferenceamygdalaanandamideendocannabinoidestrousfearhippocampusmicepost-traumatic stress disorderprefrontal cortex

Identifiers

PMID31561480
PMCPMC6827354
OpenAlexW2975084583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.