ArticleJournal of clinical medicine2019
Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Beyond Tissue Origin: Rethinking Experimental Model Selection in Rotator Cuff Research.Medical sciences (Basel, Switzerland) · 2026Article
- Rotator cuff calcifications in pseudoxanthoma elasticum: a comparative analysis of prevalence and anatomical distribution.Skeletal radiology · 2026Article
- Comparative analysis of different macromolecular crowding agents in human tenocyte cultures.Biomaterials and biosystems · 2026Article
- Calcific Tendinitis: A Pain-Oriented and Site-Specific Narrative Review.Pain research & management · 2026Review
- Effectiveness of Ultrasound-Guided Lavage for Rotator Cuff Calcific Tendinopathy: A Case Series Study from a Clinical and Radiological Perspective.Journal of clinical medicine · 2025Article
- Ectopic calcifications in the musculoskeletal field: the basis for preventive and curative pharmacological strategies.Clinical rheumatology · 2025Review
- Effects of adipose allograft matrix on viability of humeral head cartilage and rotator cuff tendon.BMC musculoskeletal disorders · 2025Article
- Effect of load reduction on the calcification of rat tibial tuberosity: Focus on calcification factors and chondrocyte mechanosensors.Journal of anatomy · 2025Article
- Calcified vs. Non-Calcified Tendinopathy of the Rotator Cuff: Clinical Presentations, Prognostic Implications, and Emerging Therapeutic Strategies.Journal of orthopaedics and sports medicine · 2025Article
- The impact of acromial morphology on the localization and size of calcific tendonitis in the rotator cuff.Acta orthopaedica et traumatologica turcica · 2024Article
- Pathological calcification in canine tendon-derived cells is modulated by extracellular ATP.Veterinary research communications · 2024Article
- Tendon-associated gene expression precedes osteogenesis in mid-palatal suture establishment.bioRxiv : the preprint server for biology · 2024Article
- PPP1R3A inhibits osteogenesis and negatively regulates intracellular calcium levels in calcific tendinopathy.iScience · 2023Article
- Predicting the formation of different tissue types during Achilles tendon healing using mechanoregulated and oxygen-regulated frameworks.Biomechanics and modeling in mechanobiology · 2023Article
- Heterotopic mineral deposits in intact rat Achilles tendons are characterized by a unique fiber-like structure.Journal of structural biology: X · 2023Article
- Characterization of Deposits in Calcific Tendinitis of the Shoulder: Deposits Are Composed of Large Aggregates of Highly Crystalline, Rod-Like Crystals.Orthopaedic journal of sports medicine · 2021Article
- Pro-inflammatory effects of human apatite crystals extracted from patients suffering from calcific tendinopathy.Arthritis research & therapy · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Calcific tendonitis is a frequent cause of chronic shoulder pain. Its cause is currently poorly known. The objectives of this study were to better characterize the cells and mechanisms involved in depositing apatite crystals in human tendons. Histologic sections of cadaveric calcified tendons were analyzed, and human calcific deposits from patients undergoing lavage of their calcification were obtained to perform infrared spectroscopy and mass spectrometry-based proteomic characterizations. In vitro, the mineralization ability of human rotator cuff cells from osteoarthritis donors was assessed by alizarin red or Von Kossa staining. Calcifications were amorphous areas surrounded by a fibrocartilaginous metaplasia containing hypertrophic chondrocyte-like cells that expressed tissue non-specific alkaline phosphatase (TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which are two key enzymes of the mineralization process. Calcific deposits were composed of apatite crystals associated with proteins involved in bone and cartilage development and endochondral bone growth. In vitro, tenocyte-like cells extracted from the rotator cuff were able to mineralize in osteogenic cultures, and expressed
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.