ArticleJournal of Alzheimer's disease : JAD2019
MRI Volumetric Quantification in Persons with a History of Traumatic Brain Injury and Cognitive Impairment.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Cerebellar volumes' selective association with MoCA over MMSE: a diagnostic insight into mild cognitive impairment and mild dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Forensic neuroimaging in childhood abduction, rape and murder case and trial outcome.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026Article
- Age-related volume decrease in subcortical gray matter is a part of healthy brain aging in men.Irish journal of medical science · 2025Article
- Smoking predicts brain atrophy in 10,134 healthy individuals and is potentially influenced by body mass index.NPJ dementia · 2025Article
- The normalizing properties of intracranial volume across race and sex.Brain communications · 2025Article
- Diagnostic utility of brain MRI volumetry in comparing traumatic brain injury, Alzheimer disease and behavioral variant frontotemporal dementia.BMC neurology · 2024Article
- Rate of abnormalities in quantitative MR neuroimaging of persons with chronic traumatic brain injury.BMC neurology · 2024Article
- Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden.Journal of Alzheimer's disease : JAD · 2023Article
- Neuroprotective Effects of Nanowired Delivery of Cerebrolysin with Mesenchymal Stem Cells and Monoclonal Antibodies to Neuronal Nitric Oxide Synthase in Brain Pathology Following Alzheimer's Disease Exacerbated by Concussive Head Injury.Advances in neurobiology · 2023Review
- Quantified Brain Magnetic Resonance Imaging Volumes Differentiate Behavioral Variant Frontotemporal Dementia from Early-Onset Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Brain Structure in Bilingual Compared to Monolingual Individuals with Alzheimer's Disease: Proof of Concept.Journal of Alzheimer's disease : JAD · 2020Article
- Quantitative MRI Differences Between Early versus Late Onset Alzheimer's Disease.American journal of Alzheimer's disease and other dementiasArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWhile traumatic brain injury (TBI) is recognized as a risk factor for dementia, there is lack of clinical tools to identify brain changes that may confer such vulnerability. Brain MRI volumetric quantification can sensitively identify brain atrophy.
objectiveTo characterize regional brain volume loss in persons with TBI presenting with cognitive impairment.
methodsIRB approved review of medical records in patients with cognitive decline focused on those who had documented TBI histories and brain MRI scans after TBI (n = 40, 67.7±14.5 years) with volumetric quantification by applying an FDA cleared software program. TBI documentation included head trauma mechanism. Brain volumes were compared to a normative database to determine the extent of atrophy. Correlations between these regions and global tests of cognition (MMSE in n = 17, MoCA in n = 27, n = 14 in both) were performed.
resultsMultiple regions demonstrated volume loss in TBI, particularly ventral diencephalon, putamen, and pallidum with smaller magnitude of atrophy in temporal lobes and brainstem. Lobar structures showed strongest correlations between atrophy and lower scores on MMSE and MoCA. The hippocampus, while correlated to tests of cognitive function, was the least atrophic region as a function of TBI history.
conclusionPersons with TBI history exhibit show regional brain atrophy. Several of these areas, such as thalamus and temporal lobes, also correlate with cognitive function. Alzheimer's disease atrophy was less likely given relative sparing of the hippocampi. Volumetric quantification of brain MRI in TBI warrants further investigation to further determine its clinical potential in TBI and differentiating causes of cognitive impairment.
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