ArticleJournal of Alzheimer's disease : JAD2019
Race, APOEɛ4, and Long-Term Cognitive Trajectories in a Biracial Population Sample.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 34 citations in OpenAlex.
- Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The role of polygenic risk in Alzheimer's disease prediction for African Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Methodological innovations in studying marginalized populations in research on neurodegeneration and ageing.Frontiers in aging neuroscience · 2026Review
- Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.medRxiv : the preprint server for health sciences · 2025Article
- Investigating the role of chronic stress and perceived discrimination in racial disparities in incident dementia among U.S. older adults.Social science & medicine (1982) · 2025Article
- Individualized machine-learning-based clinical assessment recommendation system.PLOS digital health · 2025Article
- Non-amnestic initial symptoms may be less prevalent in African American than White participants with Alzheimer's and mixed Lewy body and Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Dietary fats and the APOE-e4 risk allele in relation to cognitive decline: a longitudinal investigation in a biracial population sample.The journal of nutrition, health & aging · 2024Article
- Validation of the brain health index in the European Prevention of Alzheimer's Dementia cohort.Cerebral circulation - cognition and behavior · 2024Article
- Association of common infections with cognitive performance in the Baltimore Epidemiologic Catchment Area study follow-up.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort.Neurology · 2023Article
- Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Intersectionality in Alzheimer's Disease: The Role of Female Sex and Black American Race in the Development and Prevalence of Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning.International journal of geriatric psychiatry · 2023Article
- Association among race/color, gender, and intrinsic capacity: results from the ELSI-Brazil study.Revista de saude publica · 2023Article
- Female APOE ɛ4 Carriers with Slow Rates of Biological Aging Have Better Memory Performances Compared to Female ɛ4 Carriers with Accelerated Aging.Journal of Alzheimer's disease : JAD · 2023Article
- Association of Vitamin E and Cognitive Decline in Older Adults with and without the APOEɛ4 Allele: A Biracial Population-Based Community Study.Journal of Alzheimer's disease : JAD · 2023Article
- Contribution of life course cardiovascular risk factors to racial disparities in dementia incidence.Frontiers in dementia · 2023Article
- Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Dementia risk in a diverse population: A single-region nested case-control study in the East End of London.The Lancet regional health. Europe · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe association of the APOEɛ4 allele with incident Alzheimer's dementia is higher among European Americans (EAs) than African Americans (AAs), but similar for the rate of cognitive decline.
objectiveTo examine the racial differences in the association of the APOEɛ4 allele with incident Alzheimer's dementia and cognitive decline.
methodsUsing a population-based sample of 5,117 older adults (66% AAs and 63% females), we identified cognitive trajectory groups from a latent class mixed model and examined the association of the APOEɛ4 allele with these groups.
resultsThe frequency of the APOEɛ4 allele was higher among AAs than EAs (37% versus 26%). Four cognitive trajectories were identified: slow, mild, moderate, and rapid. Overall, AAs had a lower baseline global cognition than EAs, and a higher proportion had rapid (7% versus 5%) and moderate (20% versus 15%) decline, but similar mild (44% versus 46%), and lesser slow (29% versus 34%) decline compared to EAs. Additionally, 25% of AAs (13% of EAs) with mild and 5% (<1% of EAs) with slow decline were diagnosed with incident Alzheimer's dementia. The APOEɛ4 allele was associated with higher odds of rapid and moderate decline compared to slow decline among AAs and EAs, but not with mild decline.
conclusionsAAs had lower cognitive levels and were more likely to meet the cognitive threshold for Alzheimer's dementia among mild and slow decliners, explaining the attenuated association of the ɛ4 allele with incident Alzheimer's dementia among AAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.