SynthesisJournal of Alzheimer's disease : JAD2019
Enlarged Perivascular Spaces and Dementia: A Systematic Review.
Synthesis in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- A Quantitative Assessment of MRI-Visible Perivascular-Space Burden Across the Cognitive Spectrum: Associations with APOE ε4 Status and Venous Sinus Volume.Diagnostics (Basel, Switzerland) · 2026Article
- Late Cognitive or Mood Alterations With 'Status Cribrosum' and Diffuse White Matter Lesions: A New Cerebral Small Vessel Disease Phenotype Associated With Rare COL4A1 Variants Located Within Exon 23.European journal of neurology · 2026Article
- Correlation between the neutrophil-to-lymphocyte ratio and enlarged perivascular spaces in type 2 diabetes mellitus.Journal of diabetes investigation · 2026Article
- Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health.GeroScience · 2026Article
- Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Vascular Cognitive Impairment and Dementia: Clinical Features, Neuropathology, and Biomarkers.Journal of the American College of Cardiology · 2026Review
- "Mind the Gap"-enlarged perivascular spaces as a potential magnetic resonance imaging biomarker of impaired glymphatic clearance in brain disorders.Frontiers in cellular neuroscience · 2026Review
- MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Distribution of perivascular spaces distribution and relate to the clinical features of SCA3.Orphanet journal of rare diseases · 2025Article
- Focally Enlarged Perivascular Spaces in Pediatric and Adolescent Patients with Polymicrogyria-an MRI Study.Clinical neuroradiology · 2025Article
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- Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebral perivascular spaces as predictors of dementia risk and accelerated brain atrophy.medRxiv : the preprint server for health sciences · 2024Article
- Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD).Scientific reports · 2024Article
- Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Sensitivity and Specificity of the Boston Criteria Version 2.0 for the Diagnosis of Cerebral Amyloid Angiopathy in a Community-Based Sample.Neurology · 2024Article
- Arterial spin labeling signal in the CSF: Implications for partial volume correction and blood-CSF barrier characterization.NMR in biomedicine · 2023Article
- The elusive brain perivascular fibroblast: a potential role in vascular stability and homeostasis.Frontiers in cardiovascular medicine · 2023Review
- Enlarged Perivascular Spaces and Age-Related Clinical Diseases.Clinical interventions in aging · 2023Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perivascular compartments surrounding the penetrating arteries in the brain are part of a physiologic system, which facilitates fluids exchange and clearance of solutes from the brain. The perivascular compartments become visible on MRI when enlarged and are commonly referred to as perivascular spaces (ePVS). Previous studies on the association between ePVS and dementia have been inconsistent due to varying methods of measuring ePVS. As a frame of reference for future MRI studies on ePVS, we systematically review the literature on ePVS as a marker of vascular brain injury related to dementia from population-based as well as hospital-based settings. We identified three longitudinal and ten cross-sectional studies involving 7,581 persons. Potential outcomes were all-cause dementia, Alzheimer's disease, and vascular dementia. There was considerable heterogeneity in ePVS assessment: with studies using either visual inspection or segmentation, examining different brain locations and implementing different grading scales. Moreover, out of the total of 13 studies, all five studies on vascular dementia reported an association with presence of basal ganglia ePVS after adjustment for age, gender, and white matter hyperintensities. For seven studies on Alzheimer's disease and all-cause dementia, the results were ambiguous. This review did not identify an independent association of ePVS with prevalent or incident dementia. Harmonized methods for ePVS assessment, tested across different populations, may benefit future MRI studies on ePVS and dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.