Evidence map›Paper›PMID 31561176›Full record

ArticleThe Journal of surgical research2020

Complications and Survivorship Trends After Primary Debulking Surgery for Ovarian Cancer.

Zhaomin Xu, Adan Z Becerra, Carla F Justiniano, Christopher T Aquina, Fergal J Fleming, Francis P Boscoe, Maria J Schymura, Abdulrahman K Sinno, Jessica Chaoul, Gary R Morrow and 2 more

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In one paragraph

Article in The Journal of surgical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Zhaomin XuDepartment of Surgery, Surgical Health Outcomes and Research Enterprise, University of Rochester Medical Center, Rochester, New York.
Adan Z BecerraDepartment of Surgery, Surgical Health Outcomes and Research Enterprise, University of Rochester Medical Center, Rochester, New York; Department of Public Health Sciences, Social & Scientific Systems, Silver Spring, Maryland. Electronic address: abecerra@s-3.com.
Carla F JustinianoDepartment of Surgery, Surgical Health Outcomes and Research Enterprise, University of Rochester Medical Center, Rochester, New York.
Christopher T AquinaDepartment of Surgery, Surgical Health Outcomes and Research Enterprise, University of Rochester Medical Center, Rochester, New York.
Fergal J FlemingDepartment of Surgery, Surgical Health Outcomes and Research Enterprise, University of Rochester Medical Center, Rochester, New York.
Francis P BoscoeNew York State Cancer Registry, New York State Department of Health, Albany, New York.
Maria J SchymuraNew York State Cancer Registry, New York State Department of Health, Albany, New York.
Abdulrahman K SinnoDepartment of Gynecology and Obstetrics, Olive View-UCLA Medical Center, Kagel Canyon, California.
Jessica ChaoulVirginia Commonwealth University School of Medicine, Richmond, Virginia.
Gary R MorrowDepartment of Surgery, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York.
Lori MinasianDivision of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
Sarah M TemkinDepartment of Ob/Gyn, Virginia Commonwealth University Medical Center, Richmond, Virginia.

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Clinical and Translational Cancer Control Research Training ProgramT32CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, Gary R Morrow · 2019 to 2026
$2.7M
NCI NIH HHS T32 CA102618NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

backgroundWe examined factors associated with postoperative complications, 1-year overall and cancer-specific survival after epithelial ovarian cancer (EOC) diagnosis.

methodsPatients who underwent surgery for EOC between 2004 and 2013 were included. Multivariable models analyzed postoperative complications, overall survival, and cancer-specific survival.

resultsAmong 5223 patients, surgical complications were common. Postoperative complications correlated with increased odds of overall and disease-specific survival at 1 y. Receipt of chemotherapy was similar among women with and without postoperative complications and was independently associated with a reduction in the hazard of overall and disease-specific death at 1-year. Extensive pelvic and upper abdomen surgery resulted in 2.26 times the odds of postoperative complication, but was associated with longer 1-year overall 0.53 (0.35, 0.82) and disease-specific survival 0.54 (0.34, 0.85).

conclusionsAlthough extent of surgery was associated with complications, the survival benefit from comprehensive surgery offset the risk. Tailored surgical treatment for women with EOC may improve outcomes.

Indexed as

AgedCancer SurvivorsCarcinoma, Ovarian EpithelialCytoreduction Surgical ProceduresDisease-Free SurvivalFemaleHumansMiddle AgedOvarian NeoplasmsPostoperative ComplicationsRegistriesRetrospective StudiesSurvival RateTime FactorsOperativeOutcomes researchOvarian neoplasmsSurgical procedures

Identifiers

PMID31561176
PMCPMC6917987

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.