ArticleMolecular plant pathology2019
Major exopolysaccharide, EPS I, is associated with the feedback loop in the quorum sensing of Ralstonia solanacearum strain OE1-1.
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 35 citations in OpenAlex.
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- Two ferric uptake regulator proteins inApplied and environmental microbiology · 2026Article
- Contribution of a Novel TetR/AcrR Family Transcriptional Regulator RalT of Ralstonia pseudosolanacearum Strain OE1-1 to the Fine-Tuning of Its Virulence.MicrobiologyOpen · 2026Article
- Molecular Dialog ofInternational journal of molecular sciences · 2025Review
- The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes inMicrobiology spectrum · 2025Article
- Development of antibody to virulence factor flagellin and its evaluation in screening Ralstonia pseudosolanacearum.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Antibacterial Activity and Mechanism of Three Root Exudates from Mulberry Seedlings againstPlants (Basel, Switzerland) · 2024Article
- Efficacy of 2,4-Di-ACS omega · 2024Article
- The transcription regulator ChpA affects the global transcriptome including quorum sensing-dependent genes in Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2023Article
- Quorum Sensing-Dependent Invasion of Ralstonia solanacearum into Fusarium oxysporum Chlamydospores.Microbiology spectrum · 2023Article
- β-1,4-Cellobiohydrolase is involved in full expression of phcA, contributing to the feedback loop in quorum sensing of Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2023Article
- Identification of quorum sensing-regulatedFrontiers in microbiology · 2023Article
- Discovery of Two Novel Oxidases Using a High-Throughput Activity Screen.Chembiochem : a European journal of chemical biology · 2022Article
- Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Biomolecules · 2022Article
- Markerless gene deletion inFrontiers in microbiology · 2022Article
- Comprehensive Analysis Reveals the Genetic and Pathogenic Diversity ofFrontiers in microbiology · 2022Article
- PhcQ mainly contributes to the regulation of quorum sensing-dependent genes, in which PhcR is partially involved, in Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2021Article
- The putative sensor histidine kinase PhcK is required for the full expression of phcA encoding the global transcriptional regulator to drive the quorum-sensing circuit of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2020Article
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6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Gram-negative soil-borne bacterium Ralstonia solanacearum first infects roots of host plants and then invades xylem vessels. In xylem vessels, the bacteria grow vigorously and produce exopolysaccharides (EPSs) to cause a wilt symptom on host plants. The EPSs are thus the main virulence factors of R. solanacearum. The strain OE1-1 of R. solanacearum produces methyl 3-hydroxymyristate as a quorum-sensing (QS) signal, and senses this QS signal, activating QS. The QS-activated LysR-type transcriptional regulator PhcA induces the production of virulence-related metabolites including ralfuranone and the major EPS, EPS I. To elucidate the function of EPS I, the transcriptomes of R. solanacearum strains were analysed using RNA sequencing technology. The expression of 97.2% of the positively QS-regulated genes was down-regulated in the epsB-deleted mutant ΔepsB, which lost its EPS I productivity. Furthermore, expression of 98.0% of the negatively QS-regulated genes was up-regulated in ΔepsB. The deficiency to produce EPS I led to a significantly suppressed ralfuranone productivity and significantly enhanced swimming motility, which are suppressed by QS, but did not affect the expression levels of phcA and phcB, which encode a methyltransferase required for methyl 3-hydroxymyristate production. Overall, QS-dependently produced EPS I may be associated with the feedback loop of QS.
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