Evidence map›Paper›PMID 31560828›Full record

ReviewCancer medicine2019

Ovarian cancer: Current status and strategies for improving therapeutic outcomes.

Ashwin Chandra, Cima Pius, Madiha Nabeel, Maya Nair, Jamboor K Vishwanatha, Sarfraz Ahmad, Riyaz Basha

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05610501 (Ultrasound-guided Tru-Cut Biopsy in Pelvic Masses.), which is not on this map. Cited by 231 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
231citing papers in PubMed, 2 pooled it
38.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05610501 unknown statusnot on this mapstarted 2021, after this paper: background citation

Ultrasound-guided Tru-Cut Biopsy in Pelvic Masses.

TypeobservationalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2021 to 2025Enrolled200ConditionsPelvic Cancer, Ovarian Cancer, Cervical Cancer, Uterus CancerArmsUltrasound guided tru-cut biopsy
3 · Its place in the literature

Who cites it

231 citing papers in PubMed, 2 syntheses or guidelines pooled it, 438 citations in OpenAlex.

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171 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ashwin ChandraTexas College of Osteopathic Medicine, UNT Health Science Center, Fort Worth, TX, USA.
Cima PiusMiami Medical School, Miami, FL, USA.
Madiha NabeelGraduate School of Biomedical Sciences, UNT Health Science Center, Fort Worth, TX, USA.
Maya NairGraduate School of Biomedical Sciences, UNT Health Science Center, Fort Worth, TX, USA.
Jamboor K VishwanathaGraduate School of Biomedical Sciences, UNT Health Science Center, Fort Worth, TX, USA.
Sarfraz AhmadAdventHealth Cancer Institute, Orlando, FL, USA.
Riyaz BashaTexas College of Osteopathic Medicine, UNT Health Science Center, Fort Worth, TX, USA.ORCID 0000-0002-4071-0993
University of North Texas · USFlorida Hospital Cancer Institute · US

Funding

AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7M
Texas Minority Health, Research and Outreach (MiHERO)S21MD012472 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JAMBOOR K. VISHWANATHA · 2017 to 2026
$18.0M
Texas Center for Minority Health, Education, Research and OutreachU54MD006882 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI VISHWANATHA, JAMBOOR K. · 2017 to 2022
$6.0M
Promoting Diversity in Research Training for Health ProfessionalsR25HL125447 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI RANJAN, AMALENDU PRAKASH · 2016 to 2020
$1.0M
2/2 Pilot Project 2: Langston University-UNTHSC Partnership for Cancer Research and EducationP20CA233355 · NCI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI BASHA, RIYAZ · 2018 to 2021
$1.0M
2/2 Pilot Project 2: Langston University-UNTHSC Partnership for Cancer Research and EducationP20CA233391 · NCI · LANGSTON UNIVERSITY · PI QUINN, BYRON N · 2018 to 2021
$777k
NCI NIH HHS 1P20CA233355-01NCI NIH HHS P20 CA233355NCI NIH HHS P20 CA233391NHLBI NIH HHS R25 HL125447NHLBI NIH HHS R25HL125447NIH HHS OT2 OD032581NIMHD NIH HHS 2U54 MD006882-06NIMHD NIH HHS S21 MD012472NIMHD NIH HHS U54 MD006882
6 · The paper itself

Abstract

Of all the gynecologic tumors, ovarian cancer (OC) is known to be the deadliest. Advanced-stages of OC are linked with high morbidity and low survival rates despite the immense amount of research in the field. Shortage of promising screening tools for early-stage detection is one of the major challenges linked with the poor survival rate for patients with OC. In OC, therapeutic management is used with multidisciplinary approaches that includes debulking surgery, chemotherapy, and (rarely) radiotherapy. Recently, there is an increasing interest in using immunomodulation for treating OC. Relapse rates are high in this malignancy and averages around every 2-years. Further treatments after the relapse are more intense, increasing the toxicity, resistance to chemotherapy drugs, and financial burden to patients with poor quality-of-life. A procedure that has been studied to help reduce the morbidity rate involves pre-sensitizing cancer cells with standard therapy in order to produce optimal results with minimum dosage. Utilizing such an approach, platinum-based agents are effective due to their increased response to platinum-based chemotherapy in relapsed cases. These chemo-drugs also help address the issue of drug resistance. After conducting an extensive search with available literature and the resources for clinical trials, information is precisely documented on current research, biomarkers, options for treatment and clinical trials. Several schemes for enhancing the therapeutic responses for OC are discussed systematically in this review with an attempt in summarizing the recent developments in this exciting field of translational/clinical research.

Indexed as

AnimalsApoptosisBiomarkersCancer VaccinesDrug Resistance, MultipleDrug Resistance, NeoplasmEarly Detection of CancerFemaleHumansImmunotherapyMass ScreeningMolecular Targeted TherapyOvarian NeoplasmsBiomarkersCancer Vaccinesbiomarkersclinical trialsovarian cancerovarian cancer screening

Identifiers

PMID31560828
PMCPMC6853829
OpenAlexW2975140046

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.