ArticlePloS one2019
Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Mucosal-Associated Invariant T (MAIT) Cells in Skin Immunity: Metabolic Regulation, Tissue Adaptation, and Roles in Skin Inflammation and Disease.JID innovations : skin science from molecules to population health · 2026Review
- Antibiotic-induced gut microbiota dysbiosis and bile acid metabolism: implications for intestinal health, immune regulation, and disease susceptibility.Frontiers in microbiology · 2026Review
- Cohousing or cross-fostering followed by cohousing does not normalize the microbiomes of genetically distinct adult mice.Cell reports · 2025Article
- The interplay between host immunity andmBio · 2025Review
- Defenders or defectors: mucosal-associated invariant T cells in autoimmune diseases.Current opinion in immunology · 2025Review
- Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis.Nature communications · 2024Article
- MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis.Science immunology · 2024Article
- MR1 antigen presentation to MAIT cells and other MR1-restricted T cells.Nature reviews. Immunology · 2024Review
- Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential.Frontiers in immunology · 2024Review
- MAIT cells and the microbiome.Frontiers in immunology · 2023Review
- Evaluating Cefoperazone-Induced Gut Metabolic Functional Changes in MR1-Deficient Mice.Metabolites · 2022Article
- Geographic differences in gut microbiota composition impact susceptibility to enteric infection.Cell reports · 2021Article
- Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.Nature communications · 2021Article
- MAIT cells, guardians of skin and mucosa?Mucosal immunology · 2021Review
- Kidney stone formation and the gut microbiome are altered by antibiotics in genetic hypercalciuric stone-forming rats.Urolithiasis · 2021Article
- Establishment of murine gut microbiota in gnotobiotic mice.iScience · 2021Article
- Mouse models illuminate MAIT cell biology.Molecular immunology · 2021Review
- Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis.eLife · 2020Article
- The dialogue between unconventional T cells and the microbiota.Mucosal immunology · 2020Review
- Bile Acid Profile and its Changes in Response to Cefoperazone Treatment in MR1 Deficient Mice.Metabolites · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium difficile (Cd) infection (CDI) typically occurs after antibiotic usage perturbs the gut microbiota. Mucosa-associated invariant T cells (MAIT) are found in the gut and their development is dependent on Major histocompatibility complex-related protein 1 (MR1) and the host microbiome. Here we were interested in determining whether the absence of MR1 impacts resistance to CDI. To this end, wild-type (WT) and MR1-/- mice were treated with antibiotics and then infected with Cd spores. Surprisingly, MR1-/- mice exhibited resistance to Cd colonization. 16S rRNA gene sequencing of feces revealed inherent differences in microbial composition. This colonization resistance was transferred from MR1-/- to WT mice via fecal microbiota transplantation, suggesting that MR1-dependent factors influence the microbiota, leading to CDI susceptibility.
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