ArticlePLoS neglected tropical diseases2019
Deprivation of dietary fiber enhances susceptibility of mice to cryptosporidiosis.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Anti-Open veterinary journal · 2026Article
- Gut Barrier Dysfunction and Microbiota Variations in Cryptosporidiosis: A Comprehensive Review.Veterinary sciences · 2025Review
- Impact of predicted microbiota tryptophanase activity on Cryptosporidium parvum proliferation.PloS one · 2025Article
- The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024Review
- Fecal microbiota impacts development of Cryptosporidium parvum in the mouse.Scientific reports · 2024Article
- Review
- Early immune and host cell responses toFrontiers in parasitology · 2023Article
- Case Report: The impact of severe cryptosporidiosis on the gut microbiota of a pediatric patient with CD40L immunodeficiency.Frontiers in cellular and infection microbiology · 2023Article
- Development of Two Mouse Models for Vaccine Evaluation against Cryptosporidiosis.Infection and immunity · 2022Article
- Effect of Caging onMicroorganisms · 2022Article
- A Modern-World View of Host-Microbiota-Pathogen Interactions.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Observational
- Cryptosporidiosis and Giardiasis in Buffaloes (Frontiers in veterinary science · 2020Review
- Update on Cryptosporidium spp.: highlights from the Seventh International Giardia and Cryptosporidium Conference.Parasite (Paris, France) · 2020Review
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Based on our initial observations showing that mice consuming a probiotic product develop more severe cryptosporidiosis, we investigated the impact of other dietary interventions on the intracellular proliferation of Cryptosporidium parvum and C. tyzzeri in the mouse. Mice were orally infected with oocysts and parasite multiplication measured by quantifying fecal oocyst output. High-throughput sequencing of 16S ribosomal RNA amplicons was used to correlate oocyst output with diet and with the composition of the intestinal microbiota. On average, mice fed a diet without fiber (cellulose, pectin and inulin) developed more severe infections. As expected, a diet without fibers also significantly altered the fecal microbiota. Consistent with these observations, mice fed a prebiotic product sold for human consumption excreted significantly fewer oocysts. The fecal microbiota of mice consuming no plant polysaccharides was characterized by a lower relative abundance of Bacteroidetes bacteria. Since bacterial metabolites play an important role in the physiology of intestinal enterocytes, we hypothesize based on these observations that the impact of diet on parasite proliferation is mediated primarily by the metabolic activity of the anaerobic microbiota, specifically by the effect of certain metabolites on the host. This model is consistent with the metabolic dependence of intracellular stages of the parasite on the host cell. These observations underscore the potential of dietary interventions to alleviate the impact of cryptosporidiosis, particularly in infants at risk of recurrent enteric infections.
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Registered trials
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