SynthesisPreventing chronic disease2019
Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review.
Synthesis in Preventing chronic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Periodontal disease and cardiovascular disease: umbrella review.BMC oral health · 2024Pooled it
- Oral-health-related quality of life in adolescents: umbrella review.BMC public health · 2023Pooled it
- Association of Oral Health Assessment Tool Findings With Periodontal Screening Outcomes in Adults With Diabetes.Clinical and experimental dental research · 2026Article
- Article
- Who Gets Dental Caries? A Comprehensive Review.Dentistry journal · 2026Review
- [Utilisation of dental check-ups in Germany-prevalence and trends based on routine statutory health insurance data].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Article
- Discontinuation of dental care and systemic diseases of persons in need of long-term home care - an observational study from the InSEMaP project with German health insurance claims data.BMC geriatrics · 2026Observational
- Association of Edentulism With Subsequent Biological Age: A Cohort Study.Journal of clinical periodontology · 2026Article
- Associations Between Comorbidities, Medication Use and Dental Outcomes in Clinical Practice in Hail Dental Centre in Saudi Arabia: A Retrospective Study.Oral health & preventive dentistry · 2026Article
- Medicaid dental coverage and racial/ethnic variation in preventive dental care and unmet needs during pregnancy.BMC pregnancy and childbirth · 2026Article
- The oral‒gut axis in periodontal disease: a systematic review of the associated human evidence of its mechanisms and implications for patient care.Journal of oral microbiology · 2026Review
- Chronic Conditions, Multimorbidity and Their Associations With Tooth Loss, Dental Caries and Periodontal Disease: An Australian Perspective.International journal of dentistry · 2026Article
- Risk of pneumonia and mortality after routine dental scaling in patients with moderate-to-severe cerebral palsy: A nationwide cohort study.Journal of dental sciences · 2026Article
- Identification of Important and Relevant Functioning-Based Outcomes for Persons With an Oral Health Condition From the Patient's Perspective.Journal of oral rehabilitation · 2026Article
- End-to-end CNN-based detection of permanent first molars and prediction of root development stages from panoramic radiographs.Scientific reports · 2025Article
- Poor oral health, related quality of life, and use of dental care system among vulnerable migrants in Denmark - a cross-sectional study.Acta odontologica Scandinavica · 2025Article
- Oral Health: A Major Global Public Health Concern.Journal of clinical medicine · 2025Article
- Association of tooth brushing behavior with risks of major chronic health outcomes: a scoping review.BMC oral health · 2025Article
- Self-perceived oral health of people with and without diabetes mellitus: results of the study GEDA 2019/2020-EHIS.Journal of health monitoring · 2025Article
- Investigating the link between oral health conditions and systemic diseases: A cross-sectional analysis.Scientific reports · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionStudies have investigated the relationships between chronic systemic and dental conditions, but it remains unclear how such knowledge can be used in clinical practice. In this article, we provide an overview of existing systematic reviews, identifying and evaluating the most frequently reported dental-chronic disease correlations and common risk factors.
methodsWe conducted a systematic review of existing systematic reviews (umbrella review) published between 1995 and 2017 and indexed in 4 databases. We focused on the 3 most prevalent dental conditions and 10 chronic systemic diseases with the highest burden of disease in Germany. Two independent reviewers assessed all articles for eligibility and methodologic quality using the AMSTAR criteria and extracted data from the included studies.
resultsOf the initially identified 1,249 systematic reviews, 32 were included for qualitative synthesis. The dental condition with most frequently observed correlations to chronic systemic diseases was periodontitis. The chronic systemic disease with the most frequently observed correlations with a dental condition was type 2 diabetes mellitus (T2DM). Most dental-chronic disease correlations were found between periodontitis and T2DM and periodontitis and cardiovascular disease. Frequently reported common risk factors were smoking, age, sex, and overweight. Using the AMSTAR criteria, 2 studies were assessed as low quality, 26 studies as moderate quality, and 4 studies as high quality.
conclusionThe quality of included systematic reviews was heterogeneous. The most frequently reported correlations were found for periodontitis with T2DM and for periodontitis with cardiovascular disease. However, the strength of evidence for these and other disease correlations is limited, and the evidence to assess the causality of these disease correlations remains unclear. Future research should focus on the causality of disease links in order to provide more decisive evidence with respect to the design of intersectoral care processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.