ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Previous Syphilis Alters the Course of Subsequent Episodes of Syphilis.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Routinized Syphilis Screening Among Men Living With Human Immunodeficiency Virus: A Stepped Wedge Cluster Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Trial
- A 12-year hospital-based surveillance of syphilis in Hanzhong, China: shifting epidemics and implications for targeted prevention.BMC public health · 2026Article
- Clinical development and performance of the First to Know Syphilis Self-Test for over-the-counter usage: aJournal of clinical microbiology · 2025Article
- Review
- Syphilis-Naive Patients Achieve Treatment Success More Quickly: A Comparison of Time to Syphilis Treatment Success in Patients With Repeat Versus Naive Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- A Middle Aged Gentleman Presenting with Subacute Neurosyphilis: Report and Literature Review.Journal of community hospital internal medicine perspectives · 2022Article
- Correlates of prevalent syphilis infection among men who have sex with men (MSM) living with HIV attending the HIV clinic in Trinidad.PloS one · 2022Article
- A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines.Pathogens (Basel, Switzerland) · 2021Review
- Patient perspectives on the implementation of routinised syphilis screening with HIV viral load testing: Qualitative process evaluation of the Enhanced Syphilis Screening Among HIV-positive Men trial.BMC health services research · 2021Article
- Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection.PLoS neglected tropical diseases · 2020Article
Corrections and comments
- Correction · 2021-04-14Error in Data · Updated to Retraction ·
- Retraction · 2021-05-17Date of Article and/or Notice Unknown · Error in Data · Error in Methods · Retract and Replace · Upgrade/Update of Prior Notice(s) · · HTML overwrite, date of retraction estimated from date of republication (see: https://academic.oup.com/cid/article/74/4/e1/6277029)
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIndividuals with previous syphilis may be more likely to be asymptomatic when they are reinfected with Treponema pallidum.
methodsIndividuals enrolled in a study of cerebrospinal fluid (CSF) abnormalities in syphilis were allowed to enroll in the study again with subsequent syphilis. For each participant, the index episode was defined as the most recent syphilis episode for which the study entry visit was performed within 30 days of the syphilis diagnosis date. Venipuncture and lumbar puncture were performed. The total number of syphilis episodes was determined by review of medical and public health records. Treponema pallidum DNA in blood and rRNA in CSF were detected using polymerase chain reaction (PCR) and reverse transcriptase PCR. Odds ratios (ORs) with 95% confidence intervals (CIs) were determined using logistic regression.
results701 individuals had 1 (n = 478), 2 (n = 155), or ≥3 (n = 68) episodes of syphilis. The proportion of individuals whose index episode was asymptomatic significantly increased with increased number of syphilis episodes (P < .001). This difference was not explained by frequency of serological tests. Adjusted ORs (aORs) of detection of T. pallidum DNA in blood or rRNA in CSF at the index episode were significantly lower in those with previous syphilis (0.13; 95% CI, .08-.23, and 0.06, 95% CI, .02-.17). The aOR of neurosyphilis at the index episode was also significantly lower in individuals with previous syphilis (0.43; 95% CI, .27-.68).
conclusionsPrevious syphilis attenuates clinical and laboratory manifestations of infection with T. pallidum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.