Evidence map›Paper›PMID 31560295›Full record

ArticleCurrent radiopharmaceuticals2020

Analysis of Unusual Adverse Effects After Radium-223 Dichloride Administration.

Viviana Frantellizzi, Mariano Pontico, Arianna Pani, Roberto Pani, Giuseppe De Vincentis

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Current radiopharmaceuticals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Viviana FrantellizziDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Mariano PonticoPh.D. Program in Morphogenesis and Tissue Engineering, Sapienza University of Rome, Rome, Italy.
Arianna PaniPostgraduate School of Clinical Pharmacology and Toxicology, University of Milan "Statale", Italy.
Roberto PaniDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Giuseppe De VincentisDepartment of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo our knowledge, no previous study or literature review has been performed about the effects of the extravasation of therapeutic radiopharmaceutical agents and its potential consequences, especially regarding alpha-particle emitting radiopharmaceuticals.

methodsEven if Radium-223 dichloride is known to be a relatively safe drug to manage, despite the correctness of the procedures applied , unexpected delayed adverse effects can occur. In our vast experience, we rarely observed lymphedema, even after some time, at the site of administration.

resultsManagement of lymphedema caused by radiopharmaceuticals administration has been addressed through clinical examples. The sudden intervention allowed a fast remission of the signs and symptoms complained by patients treated with Radium-223 dichloride.

conclusionThe management of adverse effects after radiopharmaceuticals administration as in case of lymphedema onset, is extremely simple. These data confirm the safety of Radium-223 treatment.

Indexed as

AgedAged, 80 and overAntineoplastic AgentsBreast NeoplasmsCompression BandagesExercise TherapyFemaleHumansLymphedemaMaleProstatic NeoplasmsRadioisotopesRadiumAntineoplastic AgentsRadioisotopesRadiumradium Ra 223 dichloridealpha particle therapylife qualitylymphedemaRa-223 dichlorideradiopharmaceutical adverse effects

Identifiers

PMID31560295
PMCPMC7527544
OpenAlexW2976884104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.