Evidence map›Paper›PMID 31560200›Full record

ArticleJournal of medicinal chemistry2019

Selective Phenylimidazole-Based Inhibitors of the

Wenhu Zhan, Hao-Chi Hsu, Trevor Morgan, Tierra Ouellette, Kristin Burns-Huang, Ryoma Hara, Adrian G Wright, Toshihiro Imaeda, Rei Okamoto, Kenjiro Sato and 8 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. MedComm · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Macrocyclic Peptides that Selectively Inhibit theJournal of medicinal chemistry · 2021
    Article
  8. Control of Toxin-Antitoxin Systems by Proteases inFrontiers in molecular biosciences · 2021
    Review
  9. Novel Treatments againstAntibiotics (Basel, Switzerland) · 2020
    Review
  10. Psoralen Derivatives as Inhibitors ofMolecules (Basel, Switzerland) · 2020
    Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Wenhu ZhanDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Hao-Chi HsuStructural Biology Program , Van Andel Institute , 333 Bostwick Avenue Northeast , Grand Rapids , Michigan 49503 , United States.
Trevor MorganCyclofluidic Limited , Biopark Broadwater Road , Welwyn Garden City AL7 3AX , U.K.
Tierra OuelletteDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Kristin Burns-HuangDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Ryoma HaraTri-Institutional Therapeutics Discovery Institute , 413 East 69th Street , New York , New York 10065 , United States.
Adrian G WrightCyclofluidic Limited , Biopark Broadwater Road , Welwyn Garden City AL7 3AX , U.K.
Toshihiro ImaedaTri-Institutional Therapeutics Discovery Institute , 413 East 69th Street , New York , New York 10065 , United States.
Rei OkamotoTri-Institutional Therapeutics Discovery Institute , 413 East 69th Street , New York , New York 10065 , United States.
Kenjiro SatoTri-Institutional Therapeutics Discovery Institute , 413 East 69th Street , New York , New York 10065 , United States.
Mayako MichinoTri-Institutional Therapeutics Discovery Institute , 413 East 69th Street , New York , New York 10065 , United States.
Manoj RamjeeCyclofluidic Limited , Biopark Broadwater Road , Welwyn Garden City AL7 3AX , U.K.
Kazuyoshi AsoTri-Institutional Therapeutics Discovery Institute , 413 East 69th Street , New York , New York 10065 , United States.
Peter T MeinkeTri-Institutional Therapeutics Discovery Institute , 413 East 69th Street , New York , New York 10065 , United States.
Michael FoleyTri-Institutional Therapeutics Discovery Institute , 413 East 69th Street , New York , New York 10065 , United States.
Carl F NathanDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Huilin LiStructural Biology Program , Van Andel Institute , 333 Bostwick Avenue Northeast , Grand Rapids , Michigan 49503 , United States.ORCID 0000-0001-8085-8928
Gang LinDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.ORCID 0000-0003-4797-7073
Tri-Institutional Therapeutics Discovery Institute · USCornell University · USHeptares Therapeutics (United Kingdom) · GBVan Andel Institute · US

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Structure Biology of Mycobacterium Tuberculosis Pup-Proteasome PathwayR01AI070285 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI LI, HUILIN · 2007 to 2022
$6.5M
Species selective dipeptide inhibitors for Mtb proteasomeR21AI101393 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI LIN, GANG · 2013 to 2014
$465k
NCATS NIH HHS UL1 TR002384NIAID NIH HHS R01 AI070285NIAID NIH HHS R21 AI101393
6 · The paper itself

Abstract

Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Coevolving with its human host,

Indexed as

ImidazolesMicrobial Sensitivity TestsMycobacterium tuberculosisProteasome InhibitorsReactive Nitrogen SpeciesStructure-Activity RelationshipImidazolesProteasome InhibitorsReactive Nitrogen Species

Identifiers

PMID31560200
PMCPMC7091493
OpenAlexW2976893471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.