Evidence map›Paper›PMID 31559918›Full record

ArticlePharmacogenomics2019

Bayesian modeling to predict malignant hyperthermia susceptibility and pathogenicity of

Senthilkumar Sadhasivam, Barbara W Brandom, Richard A Henker, John J McAuliffe

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02964481 (Donation of Blood for Genetic Testing With Clinical Data From the North American Malignant Hyperthermia Registry), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02964481 terminatednot on this map

Donation of Blood for Genetic Testing With Clinical Data From the North American Malignant Hyperthermia Registry

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2015 to 2017Enrolled64ConditionsMalignant HyperthermiaArmsWhole exome sequencing
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Senthilkumar SadhasivamDepartment of Anesthesia, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Barbara W BrandomThe North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States (MHAUS), Department of Nurse Anesthesia, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Richard A HenkerThe North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States (MHAUS), Department of Nurse Anesthesia, University of Pittsburgh, Pittsburgh, PA 15261, USA.
John J McAuliffeDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, The University of Cincinnati, Cincinnati, OH 45229, USA.
American Association of Nurse Anesthetists · USIndiana University – Purdue University Indianapolis · USUniversity of Cincinnati · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Pharmacogenetics of Oxycodone, Personalized Care and Persistent Surgical PainR01HD089458 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SADHASIVAM, SENTHILKUMAR · 2016 to 2020
$2.5M
Bedside prediction of opioid-induced respiratory depression in children with pupillometryR21HD094311 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2019
$433k
NCATS NIH HHS UL1 TR001425NICHD NIH HHS R01 HD089458NICHD NIH HHS R21 HD094311
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptor Proteins, Signal TransducingBayes TheoremCalcium Channels, L-TypeDisease SusceptibilityExome SequencingExonsFemaleGenetic VariationGenotypeHumansMaleMalignant HyperthermiaMutationRyanodine Receptor Calcium Release ChannelAdaptor Proteins, Signal TransducingCACNA1S protein, humanCalcium Channels, L-TypeRyanodine Receptor Calcium Release ChannelRYR1 protein, humanStac3 protein, humanCACNA1Scontracture testexomegeneticmalignant hyperthermiamusclenext-generation sequencingnovelpathologicRYR1STAC3

Identifiers

PMID31559918
PMCPMC7006767
OpenAlexW2976981076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.