Evidence map›Paper›PMID 31559909›Full record

ArticleRNA biology2020

Neuronal-specific microexon splicing of

Simona Capponi, Nadja Stöffler, Manuel Irimia, Frederik M A Van Schaik, Mercedes M Ondik, Martin L Biniossek, Lisa Lehmann, Julia Mitschke, Marit W Vermunt, Menno P Creyghton and 6 more

Open access · hybridAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Neurodevelopmental Disorder with Dystonia and Chorea Linked to De Novo Variants in the Splicing Regulator SRRM4.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The roles of TAF1 in neuroscience and beyond.Royal Society open science · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Exon definitive regions forMolecular therapy. Nucleic acids · 2023
    Article
  12. Non-Canonical Splicing and Its Implications in Brain Physiology and Cancer.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Dissection ofBrain communications · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 5 countries.

Simona CapponiGerman Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ) and Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.
Nadja StöfflerGerman Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ) and Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.
Manuel IrimiaEMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation, The Barcelona Institute for Science and Technology, Barcelona, Spain.
Frederik M A Van SchaikMolecular Cancer Research and Stem Cells, Regenerative Medicine Center and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0001-8924-2986
Mercedes M OndikMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Martin L BiniossekInstitute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Lisa LehmannInstitute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Julia MitschkeInstitute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marit W VermuntHubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.
Menno P CreyghtonHubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.
Ann M GraybielMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Thomas ReinheckelInstitute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Oliver SchillingInstitute of Surgical Pathology, Faculty of Medicine-University of Freiburg, Freiburg, Germany.
Benjamin J BlencoweDonnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Canada.
Jill R CrittendenMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
H Th Marc TimmersGerman Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ) and Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.ORCID 0000-0001-7062-1417
University of Freiburg · DEMcGovern Institute for Brain Research · USUniversity Medical Center Utrecht · NLUniversitat Pompeu Fabra · ESUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34' is included in the neuronal form of

Indexed as

ExonsGene Expression RegulationRNA SplicingAnimalsBrainCell DifferentiationHistone AcetyltransferasesImmunohistochemistryMiceNerve Tissue ProteinsNeurogenesisNeuronsRNA, MessengerTATA-Binding Protein Associated FactorsTranscription Factor TFIIDHistone AcetyltransferasesNerve Tissue ProteinsnSR100 protein, mouseRNA, MessengerTATA-binding protein associated factor 250 kDaTATA-Binding Protein Associated FactorsTranscription Factor TFIIDAlternative mRNA splicingbasal transcription factorsmicroexonsneurogenesisneuronal transcriptionTAF1X-linked Dystonia Parkinsonism

Identifiers

PMID31559909
PMCPMC6948980
OpenAlexW2976396569

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.