Evidence map›Paper›PMID 31559899›Full record

ArticleCell cycle (Georgetown, Tex.)2019

MicroRNA-93 regulates the neurological function, cerebral edema and neuronal apoptosis of rats with intracerebral hemorrhage through TLR4/NF-κB signaling pathway.

Yajun Shang, Shujuan Dai, Xinjie Chen, Wei Wen, Xiaolei Liu

RetractedOpen access · bronzeAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. The neurobiological regulatory mechanism of brain edema.Frontiers in cellular neuroscience · 2026
    Review
  3. Review
  4. MiRNA-93: a novel signature in human disorders and drug resistance.Cell communication and signaling : CCS · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Autophagy and apoptosis cascade: which is more prominent in neuronal death?Cellular and molecular life sciences : CMLS · 2021
    Review
  12. Review
  13. Emerging therapeutic targets for cerebral edema.Expert opinion on therapeutic targets · 2021
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yajun ShangNeurosurgery Department, First Affiliated Hospital of Kunming Medical University , Kunming , PR. China.
Shujuan DaiNeurology Department, First Affiliated Hospital of Kunming Medical University , Kunming , PR. China.
Xinjie ChenNeurology Department, First Affiliated Hospital of Kunming Medical University , Kunming , PR. China.
Wei WenNeurology Department, First Affiliated Hospital of Kunming Medical University , Kunming , PR. China.
Xiaolei LiuNeurology Department, First Affiliated Hospital of Kunming Medical University , Kunming , PR. China.
Kunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, many studies have unraveled the impact of microRNAs (miRNAs) in intracerebral hemorrhage (ICH). This study aims to explore the role of miR-93 in modulating neurological function, cerebral edema and neuronal apoptosis of rats with ICH by regulating TLR4/NF-κB signaling pathway. ICH models were constructed using Ⅶ collagenase method. The successfully modeled rats were injected with miR-93 antagomir, TLR4/NF-κB signaling pathway activator or inhibitor together with their controls. The expression of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β) and vascular endothelial growth factor (VEGF) was measured using enzyme-linked immunosorbent assay (ELISA). The expression of human aquaporin 4 (AQP-4), Caspase-3, Bax, Bcl-2 and TLR4/NF-κB signaling pathway-related proteins was also measured. MiR-93, TLR4 and NF-κB were all highly expressed in ICH, reduced miR-93 and inhibited TLR4/NF-κB signaling pathway could improve neurological function and suppress inflammation in ICH rats. Moreover, down-regulated miR-93 and suppressed TLR4/NF-κB signaling pathway were able to attenuate cerebral edema and abate pathological lesion. We have also found in this research that miR-93 knockdown as well as inhibited TLR4/NF-κB signaling pathway could relieve neuronal apoptosis in ICH rats. This study suggests that reduced miR-93 alleviates the neurological function and cerebral edema as well as repressed neuronal apoptosis of ICH rats via the inhibited activation of TLR4/NF-κB signaling pathway.

Indexed as

AnimalsApoptosisbcl-2-Associated X ProteinBrain EdemaCaspase 3Cerebral HemorrhageDown-RegulationInflammationInterleukin-1betaInterleukin-6MicroRNAsMicroscopy, Electron, TransmissionNervous System DiseasesNeuronsNF-kappa BRatsBax protein, ratbcl-2-Associated X ProteinCasp3 protein, ratCaspase 3IL1B protein, ratIl6 protein, ratInterleukin-1betaInterleukin-6MicroRNAsMirn93 microRNA, ratNF-kappa BToll-Like Receptor 4Tumor Necrosis Factor-alphaVascular Endothelial Growth Factor AIntracerebral hemorrhageMicroRNA-93TLR4/NF-κB signaling pathway

Identifiers

PMID31559899
PMCPMC6816398
OpenAlexW2976969894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.