Evidence map›Paper›PMID 31559480›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2020

Recurrence pattern of stereotactic body radiotherapy in oligometastatic prostate cancer: a multi-institutional analysis.

Luca Nicosia, Ciro Franzese, Rosario Mazzola, Davide Franceschini, Michele Rigo, Giuseppe D'agostino, Stefanie Corradini, Filippo Alongi, Marta Scorsetti

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  15. Salvage radiotherapy in patients affected by oligorecurrent pelvic nodal prostate cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
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  16. Treatment outcomes of metastasis-directed treatment usingStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
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  18. Linac-based SBRT as a feasible salvage option for local recurrences in previously irradiated prostate cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luca NicosiaRadiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar-Verona, Italy.
Ciro FranzeseRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research Hospital, Milan-Rozzano, Italy.
Rosario MazzolaRadiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar-Verona, Italy.
Davide FranceschiniRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research Hospital, Milan-Rozzano, Italy.
Michele RigoRadiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar-Verona, Italy.
Giuseppe D'agostinoRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research Hospital, Milan-Rozzano, Italy.
Stefanie CorradiniRadiation Oncology Department, University Hospital, LMU Munich, Munich, Germany.
Filippo AlongiRadiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar-Verona, Italy. prof.filippoalongi@gmail.com.
Marta ScorsettiRadiotherapy and Radiosurgery Department, Humanitas Clinical and Research Hospital, Milan-Rozzano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFor patients with oligometastatic/oligorecurrent/oligoprogressive lymph node metastases from PCa, metastases-directed therapy is an emerging strategy. The aim of this retrospective study was to evaluate the oncological outcome and pattern of recurrence in patients treated with stereotactic body radiation therapy (SBRT) to lymph node metastases.

methodsIn this multi-institutional analysis, patients with a maximum of five lymph node metastases from PCa treated with SBRT were included. Primary endpoints of the analysis were local control (LC), out-of-field nodal progression-free survival (NPFS), overall progression-free survival (PFS), and overall survival (OS).

results109 patients and 155 lymph node metastases were evaluated. Patients' median age was 70.8 years (range 51-84) and median PSA before SBRT was 1.88 ng/ml (range 0.3-45.5 ng/ml). The dose delivered to the target ranged from 25 to 48 Gy in 4-7 fractions; median BED

conclusionSBRT is an effective and well-tolerated treatment option in the management of lymph node metastases from PCa. Prospective trials are necessary to better select patients who benefit most from this ablative focal treatment and better define the recurrence patterns.

Indexed as

AgedAged, 80 and overDisease-Free SurvivalHumansLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm Recurrence, LocalProstatic NeoplasmsRetrospective StudiesTreatment OutcomeMetastases-directed therapiesOligometastasisProstate cancerRadiotherapyStereotactic body radiotherapy

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.