CGRP-based Migraine Therapeutics: How Might They Work, Why So Safe, and What Next?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

1. Potential neural mechanisms of acupuncture therapy on migraine: a systematic review and activation likelihood estimation meta-analysis update.Quantitative imaging in medicine and surgery · 2025
   Article
2. Interplay between cannabinoids and the neuroimmune system in migraine.The journal of headache and pain · 2024
   Review
3. Association between Malnutrition and Migraine Risk Assessed Using Objective Nutritional Indices.Nutrients · 2023
   Article
4. CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023
   Review
5. Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine.Nutrients · 2023
   Review
6. CGRP Administration Into the Cerebellum Evokes Light Aversion, Tactile Hypersensitivity, and Nociceptive Squint in Mice.Frontiers in pain research (Lausanne, Switzerland) · 2022
   Article
7. Involvement of the cerebellum in migraine.Frontiers in systems neuroscience · 2022
   Review
8. Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor.Neurology and therapy · 2021
   Review
9. Danger and distress: Parabrachial-extended amygdala circuits.Neuropharmacology · 2021
   Review
10. Energy and reactivity profile and proton affinity analysis of rimegepant with special reference to its potential activity against SARS-CoV-2 virus proteins using molecular dynamics.Journal of molecular modeling · 2021
    Article
11. miR-34a-5p up-regulates the IL-1β/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons.FEBS open bio · 2021
    Article
12. Vascular actions of peripheral CGRP in migraine-like photophobia in mice.Cephalalgia : an international journal of headache · 2020
    Article
13. A proof-of-concept study on CGRP plasma levels of migraineurs during a 6-month treatment with ERENUMAB.The journal of headache and pain · 2020
    Article
14. Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice.Headache · 2020
    Article
15. Addressing chronic persistent headaches after MTBI as a neuropathic pain state.The journal of headache and pain · 2020
    Review
16. Structure and Dynamics of Adrenomedullin Receptors AMACS pharmacology & translational science · 2020
    Article
17. The Molecular Control of Calcitonin Receptor Signaling.ACS pharmacology & translational science · 2019
    Article
18. ACS pharmacology & translational science · 2019
    Article
19. Stimulation of CGRP-expressing neurons in the medial cerebellar nucleus induces light and touch sensitivity in mice.Neurobiology of pain (Cambridge, Mass.)
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author at 1 institution in 1 country.

Funding

Abstract

Indexed as