Evidence map›Paper›PMID 31559311›Full record

ArticleStem cell investigation2019

Spontaneous tumor lysis syndrome in T-cell malignancy: two case reports.

Willy Roque, Abdul Rehman, Giselle A Suero-Abreu, Barbara Anna Danek, Joseph Colao, Alla Fayngersh, Shanthi Srinivas, Joshua Kra, Donghong Cai, Victor T Chang

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Spontaneous Tumor Lysis Syndrome.Case reports in oncology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Willy RoqueDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Abdul RehmanDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Giselle A Suero-AbreuDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Barbara Anna DanekDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Joseph ColaoDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Alla FayngershDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Shanthi SrinivasSection of Hematology-Oncology, VA/New Jersey Healthcare System, East Orange, NJ, USA.
Joshua KraDivision of Hematology/Oncology, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Donghong CaiLaboratory and Pathology Services, VA New Jersey Health Care, East Orange, NJ, USA.
Victor T ChangSection of Hematology-Oncology, VA/New Jersey Healthcare System, East Orange, NJ, USA.
Rutgers, The State University of New Jersey · USRutgers New Jersey Medical SchoolVA New Jersey Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor lysis syndrome (TLS) refers to a constellation of metabolic abnormalities that result from release of intracellular solutes (potassium, phosphate, and nucleic acid metabolites) from rapidly dying tumor cells. While TLS most commonly occurs following chemotherapy, spontaneous TLS can rarely occur in rapidly dividing liquid or solid malignancies. Here, we report the cases of two patients who presented with non-specific symptoms and were found to have spontaneous TLS. Work-up in both cases led to a diagnosis of T-cell malignancy (i.e., acute lymphoblastic leukemia and angioimmunoblastic lymphoma). Given that spontaneous TLS can be the first manifestation of an underlying malignancy, all physicians should be familiar with this oncologic emergency. Early recognition and prompt management can be lifesaving for patients with an otherwise curable malignancy.

Indexed as

leukemialymphomaSpontaneous tumor lysis syndrome (spontaneous TLS)T-cell malignancy

Identifiers

PMID31559311
PMCPMC6737395
OpenAlexW2969876728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.