Evidence map›Paper›PMID 31559282›Full record

ArticleWorld journal of clinical cases2019

Multiplex gene expression profile in inflamed mucosa of patients with Crohn's disease ileal localization: A pilot study.

Francesco Giudici, Letizia Lombardelli, Edda Russo, Tiziana Cavalli, Daniela Zambonin, Federica Logiodice, Ornela Kullolli, Lamberto Giusti, Tatiana Bargellini, Marilena Fazi and 10 more

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In one paragraph

Article in World journal of clinical cases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Francesco GiudiciMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy.
Letizia LombardelliMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy.
Edda RussoMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy. edda.russo@unifi.it.
Tiziana CavalliDipartimento Chirurgico Ortopedico, Ospedale Carlo Poma di Mantova, Firenze 50134, Italy.
Daniela ZamboninMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy.
Federica LogiodiceMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy.
Ornela KullolliMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy.
Lamberto GiustiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, Firenze 50134, Italy.
Tatiana BargelliniSurgical Unit, Department of Surgery and Translational Medicine, University of Firenze, Firenze 50134, Italy.
Marilena FaziSurgical Unit, Department of Surgery and Translational Medicine, University of Firenze, Firenze 50134, Italy.
Livia BianconeDepartment of Internal Medicine, University of Roma Tor Vergata, Roma 00133, Italy.
Stefano ScaringiSurgical Unit, Department of Surgery and Translational Medicine, University of Firenze, Firenze 50134, Italy.
Ann Maria ClementeMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy.
Eloisa PerissiMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy.
Giovanni DelfinoDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, Firenze 50134, Italy.
Maria G TorciaMarie- Pierre Piccinni, Department of Experimental and Clinical Medicine, University of Firenze, Firenze 50134, Italy.
Ferdinando FicariSurgical Unit, Department of Surgery and Translational Medicine, University of Firenze, Firenze 50134, Italy.
Francesco TonelliSurgical Unit, Department of Surgery and Translational Medicine, University of Firenze, Firenze 50134, Italy.
Marie-Pierre Piccinni
Cecilia MalentacchiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, Firenze 50134, Italy.
University of Florence · ITAzienda Ospedaliera Carlo Poma · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCrohn's disease (CD) is a complex disorder resulting from the interaction of genetic, environmental, and microbial factors. The pathogenic process may potentially affect any segment of the gastrointestinal tract, but a selective location in the terminal ileum was reported in 50% of patients.

aimTo characterize clinical sub-phenotypes (colonic and/or ileal) within the same disease, in order to identify new therapeutic targets.

methods14 consecutive patients undergoing surgery for ileal CD were recruited for this study. Peripheral blood samples from each patient were collected and the main polymorphisms of the gene

resultsWe found a significant increase of Th17 (IL17A and IL17F, IL 23R and CCR6) and Th1 (IFN-γ) gene expression in inflamed mucosa compared to non-inflamed sites of 14 CD patients.

conclusionWe observed that the expression of ileal genes related to Th1 and Th17 activity is strongly activated as well as the expression of genes involved in microbiota regulation.

Indexed as

ColonCrohn’s diseaseIleumInflammationMessenger ribonucleic acidMicrobiotaTh1/Th17

Identifiers

PMID31559282
PMCPMC6745337
OpenAlexW2971445139

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.