ArticleSkin appendage disorders2019
Management and Outcome of Taxane-Induced Nail Side Effects: Experience of 79 Patients from a Single Centre.
Article in Skin appendage disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04558034 (The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer
Who cites it
4 citing papers in PubMed, 22 citations in OpenAlex.
- Adverse dermatologic effects of erdafitinib in a patient with metastatic urothelial carcinoma.Dermatology online journal · 2026Article
- Questionnaire survey of healthcare professionals on taxane-induced nail change in Japan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- The Effect of Nail Lacquer on Taxane-Induced Nail Changes in Women With Breast Cancer.Breast cancer : basic and clinical research · 2020Article
- Patient-reported Outcomes of Adverse Events After Perioperative Chemotherapy for Breast Cancer: A Prospective Observational Study.Cancer diagnosis & prognosisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNail changes are a common side effect of taxane chemotherapy, although their correct management is poorly standardized.
objectiveTo evaluate incidence, clinical aspects, and response to treatment of taxane-induced nail side effects in patients treated with taxanes for malignancies. PATIENTS AND
methodsWe performed a retrospective clinical study of 79 patients with taxane-induced nail changes from January 2015 to July 2018.
resultsPaclitaxel was the most responsible drug and both hands and feet were often affected (46.8%). Grade 2 nail toxicity was seen in 63.3% of the patients, including painful subungual hematoma, hemorrhagic onycholysis, and paronychia. Grade 3 nail toxicity was seen only in 2.5% of the patients, including hemorrhagic onycholysis and pyogenic granuloma. Removal of the detached nail plate with application of topical antibiotics and steroids induced regression of symptoms within 2 weeks.
conclusionsNail toxicity develops mostly at the end of therapy, and total drug dosage is the only known factor that predisposes to these side effects. Trauma possibly plays a role as the most severe signs are located on the great toenails. Although it is impossible to prevent taxane-induced nail side effects, a careful patient monitoring permits to immediately recognize and manage the symptoms in order to induce their remission and improvement of the patient's quality of life.
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