Evidence map›Paper›PMID 31558991›Full record

ArticleCaspian journal of internal medicine2019

Serum levels of interleukin-23 and 35 in patients with and without type 2 diabetes mellitus and chronic periodontitis.

Avideh Maboudi, Aida Eghbalian-Nouzanizadeh, Hajar Seifi, Adele Bahar, Mohadese Mohadese, Reza Ali Mohammadpour, Saeid Abediankenari, Seyedeh Leila Poorbaghi, Masood Sepehrimanesh

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In one paragraph

Article in Caspian journal of internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Serum cytokines in periodontal diseases.Periodontology 2000 · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Salivary Microbiome Profile of Diabetes and Periodontitis in a Chinese Population.Frontiers in cellular and infection microbiology · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Avideh Maboudi1.Department of Periodontics, Diabetes Research Center, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Aida Eghbalian-NouzanizadehStudent Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Hajar SeifiStudent Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Adele BaharDepartment of Internal Medicine, Diabetes Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mohadese MohadeseDental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Reza Ali MohammadpourBiostatistics Department, Health Faculty, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Saeid Abediankenari6.Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Seyedeh Leila Poorbaghi7.Obesity Prevention and Treatment Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Masood SepehrimaneshNew Iberia Research Center, University of Louisiana at Lafayette, New Iberia, Lousiana, USA.
Mazandaran University of Medical Sciences · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (DM) and chronic periodontitis (CP) show common pathophysiological features. We investigated the serum levels of IL-23 and IL-35 in people with type 2 DM and CP.

methodsIn a cross-sectional study, 72 patients were divided into four equal groups: group A, participants without type 2 DM and CP; group B, patients with type 2 DM without CP; group C, patients with CP and without type 2 DM; and group D, patients with type 2 DM and CP. Demographic data were obtained and periodontal conditions including clinical attachment loss, bleeding on probing, plaque index, gingival index, and probing depth was evaluated on all existing teeth. Fasting blood sugar (FBS) levels, hemoglobin (Hb) A1c, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were assessed. In addition, serum levels of IL-23 and 35 were measured using enzyme-linked immunosorbent assay.

resultsThe serum levels of IL-23 and 35 showed no significant differences between all groups (P>0.05). A significant positive correlation between the serum concentration of IL-23 and clinical attachment loss in the control group (r: 0.548, P=0.019) was detected. A significant negative correlation between IL-35 and the plaque index in group B (r: -0.578, P=0.012), plus significant negative correlations between IL-23 with ESR (r: -0.487, P=0.040) and CRP (r: -0.498, P=0.035) in groups C and D were also detected.

conclusionDespite significant associations of serum concentration of IL-23 and 35 with certain periodontal and inflammatory indices, neither type 2 DM nor CP differentially affects serum levels of these two cytokines.

Indexed as

Chronic periodontitisInterleukin-23Interleukin -35Type 2 diabetes mellitus

Identifiers

PMID31558991
PMCPMC6729149
OpenAlexW2963551575

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.