Evidence map›Paper›PMID 31558915›Full record

ArticleGut pathogens2019

Genome-wide mutation analysis of

Rumiko Suzuki, Kazuhito Satou, Akino Shiroma, Makiko Shimoji, Kuniko Teruya, Takashi Matsumoto, Junko Akada, Takashi Hirano, Yoshio Yamaoka

Abstract read
In one paragraph

Article in Gut pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. A critical review onFrontiers in cellular and infection microbiology · 2025
    Review
  3. Article
  4. Article
  5. Animal Models andJournal of clinical medicine · 2022
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rumiko Suzuki1Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593 Japan.
Kazuhito SatouOkinawa Institute of Advanced Sciences, 5-1 Suzaki, Uruma, Okinawa 904-2234 Japan.
Akino ShiromaOkinawa Institute of Advanced Sciences, 5-1 Suzaki, Uruma, Okinawa 904-2234 Japan.
Makiko ShimojiOkinawa Institute of Advanced Sciences, 5-1 Suzaki, Uruma, Okinawa 904-2234 Japan.
Kuniko TeruyaOkinawa Institute of Advanced Sciences, 5-1 Suzaki, Uruma, Okinawa 904-2234 Japan.
Takashi Matsumoto1Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593 Japan.
Junko Akada1Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593 Japan.
Takashi HiranoOkinawa Institute of Advanced Sciences, 5-1 Suzaki, Uruma, Okinawa 904-2234 Japan.
Yoshio Yamaoka1Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593 Japan.ORCID 0000-0002-1222-5819

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

background

resultsWe identified mutations in 21 loci of 17 genes of the post-inoculation strains. Of the 17 genes, five were outer membrane proteins that potentially influence on the colonization and inflammation. Missense and nonsense mutations were observed in 15 and 6 loci, respectively. Multiple mutations were observed in three genes. Mutated genes included

conclusionsWe confirmed mutations in genes previously reported to be associated with adaptation to Mongolian gerbils. We also listed up genes that mutated during the infection to the gerbils, though it needs experiments to prove the influence on adaptation.

Indexed as

Adaptive mutationAnimal modelGenome comparisonHelicobacter pyloriMongolian gerbilProtein structure

Identifiers

PMID31558915
PMCPMC6754630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.