Evidence map›Paper›PMID 31558911›Full record

ReviewEvidence-based complementary and alternative medicine : eCAM2019

Preclinical and Clinical Evidence Supporting Use of Cannabidiol in Psychiatry.

Gioacchino Calapai, Carmen Mannucci, Ioanna Chinou, Luigi Cardia, Fabrizio Calapai, Emanuela Elisa Sorbara, Bernardo Firenzuoli, Valdo Ricca, Gian Franco Gensini, Fabio Firenzuoli

Open access · hybridAbstract readReview
In one paragraph

Review in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  5. Effects of Cannabidiol on Locomotor Activity.Life (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Gioacchino CalapaiDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0001-8116-4821
Carmen MannucciDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0003-1292-6284
Ioanna ChinouDivision of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-6816-5261
Luigi CardiaAnesthesia, Intensive Care and Pain Therapy, A.O.U. G. Martino Messina, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0002-7286-5674
Fabrizio CalapaiDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.
Emanuela Elisa SorbaraDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.
Bernardo FirenzuoliResearch and Innovation Center in Phytotherapy and Integrated Medicine (CERFIT), Referring Center for Phytotherapy of Tuscany Region, Careggi University Hospital, Florence, Italy.
Valdo RiccaPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-9291-2124
Gian Franco GensiniPermanent Commission for Guidelines, Coordinator, Tuscany Region, Florence, Italy.
Fabio FirenzuoliResearch and Innovation Center in Phytotherapy and Integrated Medicine (CERFIT), Referring Center for Phytotherapy of Tuscany Region, Careggi University Hospital, Florence, Italy.ORCID https://orcid.org/0000-0003-1911-2021
University of Messina · ITRegione ToscanaNational and Kapodistrian University of Athens · GRUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCannabidiol (CBD) is a major chemical compound present in

objectiveThe aim of this review is to illustrate the state of art about scientific research and the evidence of effectiveness of CBD in psychiatric patients.

methodsThis review collects the main scientific findings on the potential role of CBD in the psychiatric field, and results of clinical trials carried out on psychiatric patients are commented. A research was conducted in the PUBMED, SCOPUS, and ScienceDirect databases using combinations of the words cannabidiol, psychiatry, and neuropsychiatric.

resultsPreclinical and clinical studies on potential role of CBD in psychiatry were collected and further discussed. We found four clinical studies describing the effects of CBD in psychiatric patients: two studies about schizophrenic patients and the other two studies carried out on CBD effects in patients affected by generalized social anxiety disorder (SAD).

conclusionResults from these studies are promising and suggest that CBD may have a role in the development of new therapeutic strategies in mental diseases, and they justify an in-depth commitment in this field. However, clinical evidence we show for CBD in psychiatric patients is instead still poor and limited to schizophrenia and anxiety, and it needs to be implemented with further studies carried out on psychiatric patients.

Identifiers

PMID31558911
PMCPMC6735178
OpenAlexW2971093989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.