Evidence map›Paper›PMID 31558879›Full record

SynthesisWorld journal of gastroenterology2019

Tommaso Maria Manzia, Roberta Angelico, Carlo Gazia, Ilaria Lenci, Martina Milana, Oludamilola T Ademoyero, Domiziana Pedini, Luca Toti, Marco Spada, Giuseppe Tisone and 1 more

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Induction of Clinical Operational Tolerance Through Immunosuppression Minimization: Less Is More?Liver international : official journal of the International Association for the Study of the Liver · 2026
    Review
  3. Incidence, screening, and management ofWorld journal of transplantation · 2025
    Review
  4. Review
  5. Review
  6. Side Effects of Immunosuppressant Drugs After Liver Transplant.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Complications in Post-Liver Transplant Patients.Journal of clinical medicine · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Ex vivo generation of regulatory T cells from liver transplant recipients using costimulation blockade.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  17. Successful pancreatoduodenectomy ofFrontiers in surgery · 2022
    Article
  18. Article
  19. Adult Stem Cell Therapy as Regenerative Medicine for End-Stage Liver Disease.Advances in experimental medicine and biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Tommaso Maria ManziaHPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome 00133, Italy. tomanzia@libero.it.
Roberta AngelicoDivision of Abdominal Transplantation and HPB Surgery, Bambino Gesù Children's Hospital IRCCS, Rome 00165, Italy.
Carlo GaziaHPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome 00133, Italy.
Ilaria LenciHepatology and Liver Transplant Unit, University of Tor Vergata, Rome 00133, Italy.
Martina MilanaHepatology and Liver Transplant Unit, University of Tor Vergata, Rome 00133, Italy.
Oludamilola T AdemoyeroWake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, United States.
Domiziana PediniDivision of Abdominal Transplantation and HPB Surgery, Bambino Gesù Children's Hospital IRCCS, Rome 00165, Italy.
Luca TotiHPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome 00133, Italy.
Marco SpadaDivision of Abdominal Transplantation and HPB Surgery, Bambino Gesù Children's Hospital IRCCS, Rome 00165, Italy.
Giuseppe TisoneHPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome 00133, Italy.
Leonardo BaiocchiHepatology and Liver Transplant Unit, University of Tor Vergata, Rome 00133, Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities.

aimTo study the role of immunosuppression on the incidence of

methodsA systematic literature examination about

resultsEmerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected

conclusionThe selected populations of tolerant pediatric and adult liver transplant recipients greatly benefit from immunosuppression weaning. There is still no strong clinical evidence on the usefulness of immunosuppression withdrawal in OLT recipients on malignancies. An interesting focus is represented by the complete reconstitution of the immunological pathways that could help in decreasing the incidence of

Indexed as

Patient SelectionAdultAllograftsChildGraft RejectionHumansImmune ToleranceImmunosuppression TherapyImmunosuppressive AgentsIncidenceLiverLiver TransplantationNeoplasmsPostoperative ComplicationsWithholding TreatmentImmunosuppressive AgentsAdult liver transplantCancerClinical operational toleranceDe novo malignanciesGraft rejectionImmune systemImmunosuppression minimizationImmunosuppression weaningPediatric liver transplant

Identifiers

PMID31558879
PMCPMC6761240
OpenAlexW2973851184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.