Evidence map›Paper›PMID 31558776›Full record

ArticleCell death and differentiation2020

T-cell receptor signal strength and epigenetic control of Bim predict memory CD8

Kun-Po Li, Brian H Ladle, Sema Kurtulus, Allyson Sholl, Sharmila Shanmuganad, David A Hildeman

Open access · hybridAbstract read
In one paragraph

Article in Cell death and differentiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Epigenetic insights and innovations for overcoming barriers in CAR-T cell therapy for cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Eosinophils promote CD8Signal transduction and targeted therapy · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Memory and Memory-Like NK Cell Responses to Microbial Pathogens.Frontiers in cellular and infection microbiology · 2020
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kun-Po LiImmunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Brian H LadleCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Sema KurtulusImmunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Allyson ShollDivision of Immunobiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Sharmila ShanmuganadImmunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
David A HildemanImmunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA. David.Hildeman@cchmc.org.ORCID http://orcid.org/0000-0002-0421-8483
Cincinnati Children's Hospital Medical Center · US

Funding

Homeostasis and function of regulatory T cells in agingR01AG033057 · NIA · CINCINNATI CHILDRENS HOSP MED CTR · PI CHOUGNET, CLAIRE A., HILDEMAN, DAVID A · 2009 to 2018
$3.5M
Regulation of Apoptosis in Activated Primary T CellsR01AI057753 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A · 2005 to 2013
$2.8M
Manipulating DNA Damage-response Signaling for the Treatment of Type 1 DiabetesR01DK117632 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI KATZ, JONATHAN DAVID · 2019 to 2022
$1.8M
Exploiting the DNA damage response to selectively sculpt the T cellrepertoireR01AI109810 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A, JORDAN, MICHAEL · 2014 to 2017
$1.6M
Control of Diabetes by Manipulation of Bc12 Family MembersR01DK081175 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A, KATZ, JONATHAN DAVID · 2011 to 2014
$1.4M
NIAID NIH HHS R01 AI057753NIAID NIH HHS R01 AI109810NIA NIH HHS R01 AG033057NIDDK NIH HHS R01 DK081175NIDDK NIH HHS R01 DK117632
6 · The paper itself

Abstract

Most effector CD8

Indexed as

Epigenesis, GeneticSignal TransductionAnimalsBcl-2-Like Protein 11CD8-Positive T-LymphocytesCell LineageCell SurvivalDNA MethylationGenes, ReporterImmunologic MemoryMice, Inbred C57BLNuclear Receptor Subfamily 4, Group A, Member 1Promoter Regions, GeneticReceptors, Antigen, T-CellBcl-2-Like Protein 11Nr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Receptors, Antigen, T-Cell

Identifiers

PMID31558776
PMCPMC7206134
OpenAlexW2976585327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.