ArticleNature communications2019
A 'parameiosis' drives depolyploidization and homologous recombination in Candida albicans.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Host skin lipids triggerbioRxiv : the preprint server for biology · 2026Article
- Meiosis-specific genes play roles in ploidy reduction inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genomic hallmarks of parasexual reproduction in three hybrid groups of the human pathogenbioRxiv : the preprint server for biology · 2026Article
- Male germ cell-specific deletion ofZoological research · 2026Article
- Parasex generates highly recombinant progeny in Candida albicans with increased virulence.Nature microbiology · 2026Article
- Distinct properties of human pathogenicmSystems · 2026Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Meiosis-specific genes play roles in ploidy reduction inbioRxiv : the preprint server for biology · 2025Article
- Patterns and mechanisms of fungal genome plasticity.Current biology : CB · 2025Review
- Aneuploidy confers a unique transcriptional and phenotypic profile to Candida albicans.Nature communications · 2025Article
- The dynamics of loss of heterozygosity events in genomes.EMBO reports · 2025Review
- Evolution and strain diversity advance exploration ofmSphere · 2024Review
- Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum.PLoS genetics · 2024Article
- Mendelian segregation and high recombination rates facilitate genetic analyses inbioRxiv : the preprint server for biology · 2024Article
- The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress.Annual review of microbiology · 2023Review
- Population genomics reveals meiotic recombination inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens.BMC biology · 2023Article
- On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Fungal resilience and host-pathogen interactions: Future perspectives and opportunities.Parasite immunology · 2023Review
- Ploidy changes in human fungal pathogens: Going beyond sexual reproduction.PLoS pathogens · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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Abstract
Meiosis is a conserved tenet of sexual reproduction in eukaryotes, yet this program is seemingly absent from many extant species. In the human fungal pathogen Candida albicans, mating of diploid cells generates tetraploid products that return to the diploid state via a non-meiotic process of depolyploidization known as concerted chromosome loss (CCL). Here, we report that recombination rates are more than three orders of magnitude higher during CCL than during normal mitotic growth. Furthermore, two conserved 'meiosis-specific' factors play central roles in CCL as SPO11 mediates DNA double-strand break formation while both SPO11 and REC8 regulate chromosome stability and promote inter-homolog recombination. Unexpectedly, SPO11 also promotes DNA repair and recombination during normal mitotic divisions. These results indicate that C. albicans CCL represents a 'parameiosis' that blurs the conventional boundaries between mitosis and meiosis. They also reveal parallels with depolyploidization in mammalian cells and provide potential insights into the evolution of meiosis.
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