Evidence map›Paper›PMID 31558714›Full record

ArticleNature communications2019

Functional interpretation of single cell similarity maps.

David DeTomaso, Matthew G Jones, Meena Subramaniam, Tal Ashuach, Chun J Ye, Nir Yosef

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed.

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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David DeTomasoCenter for Computational Biology, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-2074-3226
Matthew G JonesBiological and Medical Informatics Graduate Program, University of California, San Francisco, CA, USA.
Meena SubramaniamBiological and Medical Informatics Graduate Program, University of California, San Francisco, CA, USA.
Tal AshuachCenter for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
Chun J YeDepartment of Epidemiology and Biostatistics, Department of Bioengineering and Therapeutic Sciences, Institute for Human Genetics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6560-3783
Nir YosefDepartment of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. niryosef@berkeley.edu.ORCID http://orcid.org/0000-0001-9004-1225

Funding

Systems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0M
BMI Bioinformatics Training GrantsT32GM067547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2003 to 2022
$6.6M
NIAID NIH HHS U19 AI090023NIGMS NIH HHS T32 GM067547
6 · The paper itself

Abstract

We present Vision, a tool for annotating the sources of variation in single cell RNA-seq data in an automated and scalable manner. Vision operates directly on the manifold of cell-cell similarity and employs a flexible annotation approach that can operate either with or without preconceived stratification of the cells into groups or along a continuum. We demonstrate the utility of Vision in several case studies and show that it can derive important sources of cellular variation and link them to experimental meta-data even with relatively homogeneous sets of cells. Vision produces an interactive, low latency and feature rich web-based report that can be easily shared among researchers, thus facilitating data dissemination and collaboration.

Indexed as

AlgorithmsComputational BiologyGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansInternetReproducibility of ResultsSequence Analysis, RNASingle-Cell Analysis

Identifiers

PMID31558714
PMCPMC6763499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.