Evidence map›Paper›PMID 31558671›Full record

ArticleHaematologica2020

Transforming activities of the

James N Fisher, Angeliki Thanasopoulou, Sabine Juge, Alexandar Tzankov, Frederik O Bagger, Max A Mendez, Antoine H F M Peters, Juerg Schwaller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. NovelCancers · 2023
    Article
  6. Article
  7. Review
  8. Haematologica · 2020
    Article
4 · The record

Corrections and comments

  • Commented on by
    2020
5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

James N FisherUniversity Children's Hospital Basel (UKBB).
Angeliki ThanasopoulouUniversity Children's Hospital Basel (UKBB).
Sabine JugeUniversity Children's Hospital Basel (UKBB).
Alexandar TzankovInstitute for Pathology, University of Basel.
Frederik O BaggerUniversity Children's Hospital Basel (UKBB).
Max A MendezUniversity Children's Hospital Basel (UKBB).
Antoine H F M PetersFaculty of Sciences, University of Basel.
Juerg SchwallerUniversity Children's Hospital Basel (UKBB) j.schwaller@unibas.ch.
University of Basel · CHUniversity Children’s Hospital Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inv(11)(p15q23), found in myelodysplastic syndromes and acute myeloid leukemia, leads to expression of a fusion protein consisting of the N-terminal of nucleoporin 98 (NUP98) and the majority of the lysine methyltransferase 2A (KMT2A). To explore the transforming potential of this fusion we established inducible iNUP98-KMT2A transgenic mice. After a median latency of 80 weeks, over 90% of these mice developed signs of disease, with anemia and reduced bone marrow cellularity, increased white blood cell numbers, extramedullary hematopoiesis, and multilineage dysplasia. Additionally, induction of

Indexed as

Leukemia, Myeloid, AcuteMyelodysplastic SyndromesAnimalsFibroblastsHumansMiceMyeloid-Lymphoid Leukemia ProteinNuclear Pore Complex ProteinsOncogene Proteins, FusionMyeloid-Lymphoid Leukemia Proteinnuclear pore complex protein 98Nuclear Pore Complex ProteinsNup98 protein, humanOncogene Proteins, Fusion

Identifiers

PMID31558671
PMCPMC7327646
OpenAlexW2977104378

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.