Evidence map›Paper›PMID 31558669›Full record

ArticleHaematologica2020

Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research.

Aleksandr Lazaryan, Michelle Dolan, Mei-Jie Zhang, Hai-Lin Wang, Mohamed A Kharfan-Dabaja, David I Marks, Nelli Bejanyan, Edward Copelan, Navneet S Majhail, Edmund K Waller and 63 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

73 authors at 20 institutions in 10 countries.

Aleksandr LazaryanH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA aleksandr.lazaryan@moffitt.org.
Michelle DolanUniversity of Minnesota Medical Center, Minneapolis, MN, USA.
Mei-Jie ZhangCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Hai-Lin WangCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Mohamed A Kharfan-DabajaDivision of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL, USA.
David I MarksAdult Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, UK.
Nelli BejanyanDepartment of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL, USA.
Edward CopelanLevine Cancer Institute, Atrium Health, Carolinas HealthCare System, Charlotte, NC, USA.
Navneet S MajhailBlood & Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.
Edmund K WallerDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Nelson ChaoDivision of Cell Therapy and Hematology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Tim PrestidgeBlood and Cancer Centre, Starship Children's Hospital, Auckland, New Zealand.
Taiga NishihoriDepartment of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Partow KebriaeiDepartment of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, TX, USA.
Yoshihiro InamotoDivision of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Betty HamiltonBlood & Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.
Shahrukh K HashmiDepartment of Internal Medicine, Mayo Clinic, MN, USA.
Rammurti T KambleDivision of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Ulrike BacherDepartment of Hematology, Inselspital, Bern University Hospital, Switzerland.
Gerhard C HildebrandtMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Patrick J StiffLoyola University Medical Center, Maywood, IL, USA.
Joseph McGuirkUniversity of Kansas Medical Center, Westwood, KS, USA.
Ibrahim AldossCity of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Amer M BeitinjanehUniversity of Miami, Miami, FL, USA.
Lori MufflyDivision of Blood and Marrow Transplantation, Stanford University, Stanford, CA, USA.
Ravi VijDivision of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Richard F OlssonDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Michael ByrneVanderbilt University Medical Center, Nashville, TN, USA.
Kirk R SchultzDepartment of Pediatric Hematology, Oncology and Bone Marrow Transplant, British Columbia's Children's Hospital, The University of British Columbia, Vancouver, British Columbia, Canada.
Mahmoud AljurfOncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Matthew SeftelDepartment of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
Mary Lynn SavoieTom Baker Cancer Centre, Calgary, Alberta, Canada.
Bipin N SavaniDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Leo F VerdonckDepartment of Hematology/Oncology, Isala Clinic, Zwolle, the Netherlands.
Mitchell S CairoDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, New York Medical College, Valhalla, NY, USA.
Nasheed HossainLoyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
Vijaya Raj BhattThe Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Haydar A FrangoulThe Children's Hospital at TriStar Centennial and Sarah Cannon Research Institute, Nashville, TN, USA.
Hisham Abdel-AzimDivision of Hematology, Oncology and Blood & Marrow Transplantation, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Monzr Al MalkiCity of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Reinhold MunkerSection of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport, Shreveport, LA, USA.
David RizzieriDivision of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Nandita KheraDepartment of Hematology/Oncology, Mayo Clinic, Phoenix, AZ, USA.
Ryotaro NakamuraDepartment of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
Olle RingdénTranslational Cell Therapy Group, CLINTEC (Clinical Science, Intervention and Technology), Karolinska Institutet, Stockholm Sweden.
Marjolein van der PoelAcademische Ziekenhuis Maastricht, Maastricht, the Netherlands.
Hemant S MurthyMayo Clinic Florida, Jacksonville, FL, USA.
Hongtao LiuUniversity of Chicago Medicine, Chicago, IL, USA.
Shahram MoriBlood & Marrow Transplant Center, Florida Hospital Medical Group, Orlando, FL, USA.
Satiro De OliveiraUCLA Medical Center, Los Angeles, CA, USA.
Javier Bolaños-MeadeThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Mahmoud ElsawyQE II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
Pere BarbaHospital Vall d'Hebron, Barcelona, Spain.
Sunita NathanRush University Medical Center, Chicago, IL, USA.
Biju GeorgeChristian Medical College, Vellore, India.
Attaphol PawarodeBlood and Marrow Transplantation Program, Division of Hematology/Oncology, Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI, USA.
Michael GrunwaldDepartment of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Vaibhav AgrawalDivision of Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
Youjin WangNational Cancer Institute (NCI), Rockville, MD, USA.
Amer AssalNew York Presbyterian Hospital/Columbia University Medical Center, New York, NY, USA.
Paul Castillo CaroUF Health Shands Children's Hospital, Gainesville, FL, USA.
Yachiyo KuwatsukaDepartment of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.
Sachiko SeoDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan.
Celalettin UstunDivision of Hematology/Oncology/Cell Therapy, Rush University, Chicago, IL, USA.
Ioannis PolitikosMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Hillard M LazarusCase Western Reserve University, Cleveland, OH, USA.
Wael SaberCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Brenda M SandmaierDivision of Medical Oncology, University of Washington and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Marcos De LimaDepartment of Medicine, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH, USA.
Mark LitzowDivision of Hematology and Transplant Center, Mayo Clinic Rochester, Rochester, MN, USA.
Veronika BachanovaBlood and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis, MN, USA.
Daniel WeisdorfDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA.
Acute Leukemia Committee of the CIBMTR
City of Hope · USMedical College of Wisconsin · USMoffitt Cancer Center · USUniversity of Minnesota Medical Center · USCleveland Clinic · USKarolinska Institutet · SEMayo Clinic in Arizona · USMayo Clinic in Florida · USVanderbilt University Medical Center · USBaylor College of Medicine · USBC Children's Hospital · CACancerCare Manitoba · CACarolinas Healthcare System · USCase Western Reserve University · USChildren’s Hospital at TriStar Centennial · USChristian Medical College, Vellore · INDokkyo Medical University · JPDuke Medical Center · USDuke University · USEmory University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.U24HL138660 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Steven M. DeVine, Mehdi Hussain Hamadani · 2017 to 2026
$71.4M
Serious Hazards of Transfusion & Cellular Therapies: Mechanisms and InterventionP01HL086773 · NHLBI · EMORY UNIVERSITY · PI ROBACK, JOHN D · 2008 to 2019
$17.9M
Genetic Epidemiology of Telomere Maintenance and Cancer EtiologyZIACP010190 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$10.2M
Immuno-Oncology Translation Network (IOTN): Cellular Immunotherapy Data Resource (CIDR)U24CA233032 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI PASQUINI, MARCELO C. · 2018 to 2019
$9.0M
Using donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantationR01AI145231 · NIAID · EMORY UNIVERSITY · PI WALLER, EDMUND K · 2020 to 2024
$3.6M
Hematopoietic Stem Cell Transplantation for Young Adults with SCD - DCCU01HL128568 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI EAPEN, MARY, MENDIZABAL, ADAM M. · 2015 to 2019
$1.7M
Using donor pDC to optimize GvHD and GvL in allogeneic stem cell transplantationR01CA188523 · NCI · EMORY UNIVERSITY · PI WALLER, EDMUND K · 2014 to 2018
$1.6M
Using donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantationR56AI145231 · NIAID · EMORY UNIVERSITY · PI WALLER, EDMUND K · 2019 to 2019
$379k
Incorporating patient reported outcomes into individualized prognostication tools for survival and quality of life in transplant patientsR21HL140314 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SHAW, BRONWEN · 2018 to 2019
$248k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA188523NCI NIH HHS U24 CA076518NHLBI NIH HHS P01 HL086773NHLBI NIH HHS R21 HL140314NHLBI NIH HHS U01 HL128568NHLBI NIH HHS U24 HL138660NIAID NIH HHS R01 AI145231NIAID NIH HHS R56 AI145231
6 · The paper itself

Abstract

Cytogenetic risk stratification at diagnosis has long been one of the most useful tools to assess prognosis in acute lymphoblastic leukemia (ALL). To examine the prognostic impact of cytogenetic abnormalities on outcomes after allogeneic hematopoietic cell transplantation, we studied 1731 adults with Philadelphia-negative ALL in complete remission who underwent myeloablative or reduced intensity/non-myeloablative conditioning transplant from unrelated or matched sibling donors reported to the Center for International Blood and Marrow Transplant Research. A total of 632 patients had abnormal conventional metaphase cytogenetics. The leukemia-free survival and overall survival rates at 5 years after transplantation in patients with abnormal cytogenetics were 40% and 42%, respectively, which were similar to those in patients with a normal karyotype. Of the previously established cytogenetic risk classifications, modified Medical Research Council-Eastern Cooperative Oncology Group score was the only independent prognosticator of leukemia-free survival (

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcutePrecursor Cell Lymphoblastic Leukemia-LymphomaAdultChromosome AberrationsHumansRetrospective StudiesTransplantation ConditioningTransplantation, Homologous

Identifiers

PMID31558669
PMCPMC7193485
OpenAlexW2975917046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.