ArticleProceedings of the National Academy of Sciences of the United States of America1985
Identification of a single chromosome in the normal human genome essential for suppression of hamster cell transformation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum.Journal of cellular and molecular medicine · 2009Review
- The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.Genes & development · 2008Article
- Low-frequency loss of heterozygosity in Moloney murine leukemia virus-induced tumors in BRAKF1/J mice.Journal of virology · 1997Article
- MYCL genotypes and loss of heterozygosity in non-small-cell lung cancer.British journal of cancer · 1996Article
- Loss of thrombospondin transcriptional activity in nickel-transformed cells.Molecular and cellular biology · 1994Article
- Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Suppression of properties associated with malignancy in murine melanoma-melanocyte hybrid cells.British journal of cancer · 1992Article
- Suppression of the chemically transformed phenotype of BHK cells by a human cDNA.Molecular and cellular biology · 1991Article
- Normal human chromosome 1 carries suppressor activity for various phenotypes of a Kirsten murine sarcoma virus-transformed NIH/3T3 cell line.Japanese journal of cancer research : Gann · 1990Article
- A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Loss of heterozygosity of the L-myc oncogene in human breast tumors.Human genetics · 1990Article
- Suppression of the progression phenotype in somatic cell hybrids occurs in the absence of altered adenovirus type 5 gene expression.Molecular and cellular biology · 1990Article
- Tumor suppression involves down-regulation of interleukin 3 expression in hybrids between autocrine mastocytoma and interleukin 3-dependent parental mast cells.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Distal deletion of chromosome Ip in ductal carcinoma of the breast.American journal of human genetics · 1989Article
- Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Recessive mechanisms of malignancy.British journal of cancer · 1988Review
- Loss of heterozygosity in hypotriploid cell cultures from testicular tumours.Human genetics · 1987Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Normal human fibroblasts were fused to carcinogen-transformed baby hamster kidney (BHK) cells and found to be able to suppress the anchorage-independent transformed phenotype of the hamster cells. This suppression was not due to interspecies incompatibility, for transformation could be effectively expressed in hybrids if either the human or the BHK parent had initially been transformed by a dominantly acting viral genome. Upon growth of suppressed hybrids, loss of human chromosomes was accompanied by the re-expression of transformation. Karyotype analysis indicated that only human chromosome 1 was retained in all hybrids that were suppressed and was lost in all hybrids in which transformation was re-expressed. Cytological evidence for the presence or absence of chromosome 1 was confirmed by electrophoretic identification of the human isozyme for phosphoglucomutase 1. Clones re-expressing transformation were isolated from two suppressed hybrids and in both cases loss of suppression was accompanied by the loss of human chromosome 1. Thus, the maintenance of suppression in these cross-species hybrids appears to require the continued presence of normal human chromosome 1. These findings raise the possibility that the frequent involvement of human chromosome 1 in potentially inactivating aberrations in human tumors may reflect a suppressor role for this chromosome in human malignancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.