Evidence map›Paper›PMID 31558608›Full record

ArticleThe Journal of biological chemistry2019

Toll-like receptor 2-dependent endosomal signaling by

Jana Musilova, Michelle E Mulcahy, Marieke M Kuijk, Rachel M McLoughlin, Andrew G Bowie

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The macrophage infectivity potentiator ofFrontiers in immunology · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Human MAIT Cells Respond toMicroorganisms · 2022
    Article
  16. Article
  17. Frontiers in cellular and infection microbiology · 2022
    Article
  18. eLife · 2021
    Article
  19. Article
  20. Pathogens (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jana MusilovaSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Michelle E MulcahySchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Marieke M KuijkSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Rachel M McLoughlinSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Andrew G BowieSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland agbowie@tcd.ie.ORCID 0000-0001-5316-4373
Trinity College Dublin · IE

Funding

Wellcome Trust
6 · The paper itself

Abstract

Pathogen activation of innate immune pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) stimulates cellular signaling pathways. This often leads to outcomes that contribute to pathogen clearance. Alternatively, activation of specific PRR pathways can aid pathogen survival. The human pathogen

Indexed as

Microbial ViabilitySignal TransductionAnimalsCell LineEndosomesHumansI-kappa B KinaseInterferon Type IMiceMonocytesStaphylococcus aureusTNF Receptor-Associated Factor 6Toll-Like Receptor 2I-kappa B KinaseInterferon Type ITLR2 protein, humanTNF Receptor-Associated Factor 6Toll-Like Receptor 2host-pathogen interactionimmune evasioninfectious diseaseinnate immunityinterferonmonocytenonprofessional phagocyteStaphylococcus aureus (S. aureus)Toll-like receptor (TLR)

Identifiers

PMID31558608
PMCPMC6851302
OpenAlexW2975240215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.