Evidence map›Paper›PMID 31558572›Full record

ArticleeNeuro

Resurgent and Gating Pore Currents Induced by

Emily R Mason, Fenfen Wu, Reesha R Patel, Yucheng Xiao, Stephen C Cannon, Theodore R Cummins

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Pathogenic gating pore current conducted by autism-related mutations in the NaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-FunctionThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Epilepsy-associatedbioRxiv : the preprint server for biology · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Emily R MasonDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202 emmason@iu.edu.
Fenfen WuDepartment of Physiology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095-1751.
Reesha R PatelProgram in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN 46202.
Yucheng XiaoSchool of Science, Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202.
Stephen C CannonDepartment of Physiology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095-1751.
Theodore R CumminsSchool of Science, Biology Department Chair, Indiana University-Purdue University of Indianapolis, Indianapolis, IN 46202.
Indiana University · USUniversity of California, Los Angeles · USIndiana University – Purdue University Indianapolis · USUniversity of Indianapolis · US

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2018 to 2022
$12.1M
Molecular Physiology of Myotonia and Periodic ParalysisR37AR042703 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI CANNON, STEPHEN C. · 2008 to 2018
$4.2M
MOLECULAR PHYSIOLOGY OF NEUROMUSCULAR DISEASESR01AR042703 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI CANNON, STEPHEN C. · 1994 to 2007
$2.4M
NIAMS NIH HHS R01 AR042703NIAMS NIH HHS R37 AR042703NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

Over 150 mutations in the

Indexed as

Action PotentialsAnimalsEpilepsyHEK293 CellsHumansIon Channel GatingNAV1.2 Voltage-Gated Sodium ChannelPoint MutationXenopus laevisNAV1.2 Voltage-Gated Sodium ChannelSCN2A protein, humanchannelopathiesepilepsygating pore currentNav1.2resurgent currentwhole-cell electrophysiology

Identifiers

PMID31558572
PMCPMC6795554
OpenAlexW2975966003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.