ArticleAnnals of hepatology
Liver transplant candidates have impaired quality of life across health domains as assessed by computerized testing.
Article in Annals of hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Effect of a Nursing Program on Anxiety, Depression, and Insomnia in Patients After Liver Transplantation: A Randomized Controlled Trial.Annals of transplantation · 2025Trial
- Adaptation before and one year after liver transplantation: a longitudinal grounded theory study.International journal of qualitative studies on health and well-being · 2026Article
- Assessment of Drug-related Problems among Patients of Chronic liver Disease in a Tertiary Care Hospital.Ethiopian journal of health sciences · 2024Observational
- Quality of life, anxiety, and depression improve at one-year after liver transplantation in patients with advanced liver disease.Frontiers in transplantation · 2024Article
- Patient-reported outcomes and patient-reported outcome measures in liver transplantation: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Identifying opportunities for hepatic encephalopathy self-management: A mixed methods systematic review and synthesis.Canadian liver journal · 2023Article
- European Society for Organ Transplantation (ESOT) Consensus Statement on Outcome Measures in Liver Transplantation According to Value-Based Health Care.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Depression and Anxiety Are Common Among Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Breaking Down Barriers to Physical Activity in Patients with Nonalcoholic Fatty Liver Disease.Digestive diseases and sciences · 2021Article
- Beyond Survival: Targeting Health-Related Quality of Life Outcomes After Liver Transplantation.Clinical liver disease · 2021Review
- Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH.Contemporary clinical trials communications · 2020Article
- The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation.Journal of clinical gastroenterologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
INTRODUCTION AND
objectivesLiver transplantation candidates are among the most comorbid patients awaiting lifesaving intervention. Health related quality of life (HRQOL) measured by instruments that incorporate dynamic computerized adaptive testing, could improve their assessment. We aimed to determine the feasibility of administration of the Patient-Reported Outcomes Measurement Information System (PROMIS-CAT) in liver transplant candidates. MATERIALS AND
methodsLiver transplantation candidates were prospectively enrolled following a review of their available medical history. Subjects were given a tablet computer (iPad) to access the pre-loaded PROMIS CAT.
results109 candidates with mean age 55.6±8.6 years were enrolled in this pilot study. Mean MELD-Na score was 16.3±6.3; 92.6% had decompensated liver disease. Leading etiologies of cirrhosis included hepatitis C (34.8%), nonalcoholic steatohepatitis (25.7%) and alcohol (21.1%). Subjects with MELD-Na score>20 had the most significant impairment in HRQOL (anxiety/fear+5.9±2.7, p=0.0289, depression+5.1±2.5, p=0.0428, fatigue+4.3±2.6, p=0.0973) and physical impairment (-7.8±2.5, p=0.0022). Stage of cirrhosis and decompensated liver disease were predictive of impaired HRQOL but Child-Pugh Turcotte score was not. Hepatic encephalopathy was the strongest independent predictor of impaired HRQOL, with significant impairment across all domains of health.
conclusionsLiver transplant candidates have significantly impaired HRQOL across multiple domains of health as measured by PROMIS-CAT. HRQOL impairment parallels disease severity. Future study is needed to determine how best HRQOL could be systematically included in liver transplantation listing policy, especially in those candidates with hepatic encephalopathy.
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