ArticleJournal of the American College of Cardiology2019
Childhood Tobacco Smoke Exposure and Risk of Atrial Fibrillation in Adulthood.
Article in Journal of the American College of Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Secondhand tobacco exposure and risk of atrial fibrillation: a systematic review.BMC public health · 2026Pooled it
- Association Between Socioeconomic Status and Atrial Fibrillation: A Two-Sample Mendelian Randomization Study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Modifiable Lifestyle Factors, Left Atrial Indices, and Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- Recent-onset atrial fibrillation: challenges and opportunities.European heart journal · 2026Review
- Modifiable predictors of atrioventricular block warranting a pacemaker: A cohort study.PloS one · 2026Article
- Knowledge, attitude, and practice toward atrial fibrillation among patients.BMC cardiovascular disorders · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Advancements in Cardiovascular Disease Research Affected by Smoking.Reviews in cardiovascular medicine · 2024Review
- Assessing Causality Between Second-Hand Smoking and Potentially Associated Diseases in Multiple Systems: A Two-Sample Mendelian Randomization Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Atrial fibrillation: comorbidities, lifestyle, and patient factors.The Lancet regional health. Europe · 2024Review
- E-cigarettes and arrhythmogenesis: a comprehensive review of pre-clinical studies and their clinical implications.Cardiovascular research · 2023Review
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- External validation and comparison of CHAJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022Article
- Review
- Association of RDW, NLR, and PLR with Atrial Fibrillation in Critical Care Patients: A Retrospective Study Based on Propensity Score Matching.Disease markers · 2022Article
- Cigarette Use among Parents with Children in the Home: A Comparison of Civilian Parents and Parents with a Military Connection.Environmental health insights · 2022Article
- Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis.International journal of endocrinology · 2022Review
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years.PloS one · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCigarette smoking is known to increase the risk of atrial fibrillation (AF), and a recent cross-sectional analysis suggested that parental smoking may be an AF risk factor.
objectivesThe purpose of this study was to assess if parental smoking predicts offspring AF in the Framingham Heart Study.
methodsThis study analyzed Framingham Offspring cohort participants with parents in the Original cohort with known smoking status during the offspring's childhood. Framingham participants were evaluated every 2 to 8 years and were under routine surveillance for incident AF. The authors assessed AF incidence among Offspring participants exposed to parental smoking through age 18 years and performed a mediation analysis to determine the extent to which offspring smoking might explain observed associations.
resultsOf 2,816 Offspring cohort participants with at least 1 parent in the Original cohort, 82% were exposed to parental smoking. For every pack/day increase in parental smoking, there was an 18% increase in offspring AF incidence (adjusted hazard ratio [HR]: 1.18; 95% confidence interval [CI]: 1.00 to 1.39; p = 0.04). Additionally, parental smoking was a risk factor for offspring smoking (adjusted odds ratio [OR]: 1.34; 95% CI: 1.17 to 1.54; p < 0.001). Offspring smoking mediated 17% (95% CI: 1.5% to 103.3%) of the relationship between parental smoking and offspring AF.
conclusionsChildhood secondhand smoke exposure predicted increased risk for adulthood AF after adjustment for AF risk factors. Some of this relationship may be mediated by a greater propensity among offspring of smoking parents to smoke themselves. These findings highlight potential new pathways for AF risk that begin during childhood, offering new evidence to motivate smoking avoidance and cessation.
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