Evidence map›Paper›PMID 31558096›Full record

ArticleToxicologic pathology2019

Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway.

Grace A Chappell, Julia E Rager, Jeffrey Wolf, Milos Babic, Kyle J LeBlanc, Caroline L Ring, Mark A Harris, Chad M Thompson

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicologic pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Crypt and Villus Transcriptomic Responses in Mouse Small Intestine Following Oral Exposure to Hexavalent Chromium.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Grace A ChappellToxStrategies, Inc, Asheville, NC, USA.ORCID 0000-0002-7543-8336
Julia E RagerToxStrategies, Inc, Austin, TX, USA.
Jeffrey WolfExperimental Pathology Laboratories, Sterling, VA, USA.
Milos BabicBioSpyder Technologies, Inc., Carlsbad, CA, USA.
Kyle J LeBlancBioSpyder Technologies, Inc., Carlsbad, CA, USA.
Caroline L RingToxStrategies, Inc, Asheville, NC, USA.
Mark A HarrisToxStrategies, Inc., Katy, TX, USA.
Chad M ThompsonToxStrategies, Inc., Katy, TX, USA.
Biospyder (United States) · USBioStrategies (United States) · USExperimental Pathology Laboratories · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Carcinogenesis of the small intestine is rare in humans and rodents. Oral exposure to hexavalent chromium (Cr(VI)) and the fungicides captan and folpet induce intestinal carcinogenesis in mice. Previously (

Indexed as

AnimalsCaptanCarcinogensChromiumGene Expression ProfilingHypoxia-Inducible Factor 1, alpha SubunitIntestine, SmallMicePhthalimidesCaptanCarcinogensChromiumchromium hexavalent ionfolpetHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitPhthalimidesadverse outcome pathwaycaptanfolpethexavalent chromiumintestinal cancermechanism of actionmode of actionrodent pathologyS1500+transcriptomics

Identifiers

PMID31558096
PMCPMC6827348
OpenAlexW2976795489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.