Evidence map›Paper›PMID 31558049›Full record

ArticleChronic respiratory disease

Physician characteristics associated with treatment initiation patterns in idiopathic pulmonary fibrosis.

Peter P LaCamera, Susan L Limb, Tmirah Haselkorn, Elizabeth A Morgenthien, John L Stauffer, Mark L Wencel

Abstract read
In one paragraph

Article in Chronic respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peter P LaCameraDepartment of Pulmonary Medicine/Respiratory Care St. Elizabeth's Medical Center, Boston, MA, USA.
Susan L LimbGenentech, Inc., South San Francisco, CA, USA.
Tmirah HaselkornEpiMetrix, Inc., Los Altos, CA, USA.
Elizabeth A MorgenthienGenentech, Inc., South San Francisco, CA, USA.ORCID 0000-0002-1733-6403
John L StaufferGenentech, Inc., South San Francisco, CA, USA.
Mark L WencelDepartment of Pulmonary Medicine Via Christi Health, Wichita, KS, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pirfenidone and nintedanib are oral antifibrotic agents approved for the treatment of idiopathic pulmonary fibrosis (IPF). Real-world data on factors that influence IPF treatment decisions are limited. Physician characteristics associated with antifibrotic therapy initiation following an IPF diagnosis were examined in a sample of US pulmonologists. An online, self-administered survey was fielded to pulmonologists between April 10, 2017, and May 17, 2017. Pulmonologists were included if they spent >20% of their time in direct patient care and had ≥5 patients with IPF receiving antifibrotics. Participants answered questions regarding timing and reasons for considering the initiation of antifibrotic therapy after an IPF diagnosis. A total of 169 pulmonologists participated. The majority (81.7%) considered initiating antifibrotic therapy immediately after IPF diagnosis all or most of the time (immediate group), while 18.3% considered it only some of the time or not at all (delayed group). Pulmonologists in the immediate group were more likely to work in private practice (26.1%), have a greater mean percentage of patients receiving antifibrotic therapy (60.8%), and decide to initiate treatment themselves (31.2%) versus those in the delayed group (16.1%, 30.5%, and 16.1%, respectively). Most pulmonologists consider initiating antifibrotic treatment immediately after establishing an IPF diagnosis all or most of the time versus using a "watch-and-wait" approach. Distinguishing characteristics between pulmonologists in the immediate group versus the delayed group included practice setting, percentage of patients receiving antifibrotic therapy, and the decision-making dynamics between the patient and the pulmonologist.

Indexed as

Practice Patterns, Physicians'Antineoplastic AgentsClinical Decision-MakingHumansIdiopathic Pulmonary FibrosisIndolesPatient ParticipationPrivate PracticePulmonary MedicinePyridonesSurveys and QuestionnairesTime FactorsUnited StatesWatchful WaitingAntineoplastic AgentsIndolesnintedanibpirfenidonePyridonesAntifibrotic therapyidiopathic pulmonary fibrosis

Identifiers

PMID31558049
PMCPMC6764076

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.