ReviewAntibodies (Basel, Switzerland)2016
Current Controversies in Lupus Anticoagulant Detection.
Review in Antibodies (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Normalization of activated partial thromboplastin time and diluted Russell's viper venom time ratios can be safely omitted in the assessment of lupus anticoagulant.Research and practice in thrombosis and haemostasis · 2026Article
- Unmasking the phospholipid-induced "hook effect" and its implications - increasing phospholipid can also lead to a longer clotting time in coagulation assays.Journal of thrombosis and thrombolysis · 2026Article
- Seronegative Catastrophic Antiphospholipid Syndrome: A Case Report of a Deadly Diagnosis.Cureus · 2024Article
- Comparison of different algorithms for lupus anticoagulant detection: a single-center experience.Research and practice in thrombosis and haemostasis · 2024Article
- Lupus Anticoagulant Detection under the Magnifying Glass.Journal of clinical medicine · 2023Review
- Homozygous Factor V Leiden Complicated by Heparin-Induced Thrombocytopenia: A Case Report.Journal of medical cases · 2022Article
- Article
- Thrombophilia testing in the era of direct oral anticoagulants.Clinical medicine (London, England) · 2021Review
- Current Promising Biomarkers and Methods in the Diagnostics of Antiphospholipid Syndrome: A Review.Biomedicines · 2021Review
- Ménétrier's disease presenting as recurrent unprovoked venous thrombosis: a case report.Journal of medical case reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antiphospholipid syndrome is an autoimmune, acquired thrombophilia diagnosed when vascular thrombosis or pregnancy morbidity are accompanied by persistent antiphospholipid antibodies. Lupus anticoagulants (LA) are one of the criteria antibodies but calibration plasmas are unavailable and they are detected by inference based on antibody behaviour in a medley of coagulation-based assays. Elevated screening tests suggest the presence of a LA, which is confirmed with mixing tests to evidence inhibition and confirmatory tests to demonstrate phospholipid-dependence. At least two screening tests of different principle must be used to account for antibody heterogeneity and controversy exists on whether assays, in addition to dilute Russell's viper venom time and activated partial thromboplastin time, should be employed. A variety of approaches to raw data manipulation and interpretation attract debate, as does inclusion or exclusion of mixing studies in circumstances where the presence of a LA is already evident from other results. Therapeutic anticoagulation compromises coagulation-based assays but careful data interpretation and use of alternative reagents can detect or exclude LA in specific circumstances, and this aspect of LA detection continues to evolve. This review focuses on the main areas of debate in LA detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.