Evidence map›Paper›PMID 31557971›Full record

ArticleGenes2019

Identification of Alternatively-Activated Pathways between Primary Breast Cancer and Liver Metastatic Cancer Using Microarray Data.

Limei Wang, Jin Li, Enze Liu, Garrett Kinnebrew, Xiaoli Zhang, Daniel Stover, Yang Huo, Zhi Zeng, Wanli Jiang, Lijun Cheng and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Cancer Drug Sensitivity Prediction Based on Deep Transfer Learning.International journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Organ-Specificity of Breast Cancer Metastasis.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Limei WangCollege of Automation, Harbin Engineering University, Harbin 150001, China. wanglm@hrbeu.edu.cn.
Jin LiDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Enze LiuThe Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN 46202, USA.
Garrett KinnebrewDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Xiaoli ZhangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Daniel StoverDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Yang HuoThe Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN 46202, USA.
Zhi ZengDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Wanli JiangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Lijun ChengDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Weixing FengCollege of Automation, Harbin Engineering University, Harbin 150001, China. fengweixing@hrbeu.edu.cn.
Lang LiDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA. Lang.Li@osumc.edu.
The Ohio State University · USHarbin Engineering University · CNIndiana University – Purdue University Indianapolis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternatively-activated pathways have been observed in biological experiments in cancer studies, but the concept had not been fully explored in computational cancer system biology. Therefore, an alternatively-activated pathway identification method was proposed and applied to primary breast cancer and breast cancer liver metastasis research using microarray data. Interestingly, the results show that

Indexed as

Gene Expression Regulation, NeoplasticMetabolic Networks and PathwaysBreast NeoplasmsCalcium SignalingCytokinesFemaleGene Expression ProfilingHumansLiver NeoplasmsOligonucleotide Array Sequence AnalysisTransforming Growth Factor betaCytokinesTransforming Growth Factor betaalternatively-activated pathwaybreast cancergene active statusliver metastasismicroarray

Identifiers

PMID31557971
PMCPMC6826985
OpenAlexW2976886728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.