Evidence map›Paper›PMID 31557968›Full record

ArticleInternational journal of molecular sciences2019

Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.

Ivan Ranđelović, Sabine Schuster, Bence Kapuvári, Gianluca Fossati, Christian Steinkühler, Gábor Mező, József Tóvári

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. Peptide-Drug Conjugates: A New Hope for Cancer.Journal of peptide science : an official publication of the European Peptide Society · 2025
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  13. Research advances in peptide‒drug conjugates.Acta pharmaceutica Sinica. B · 2023
    Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ivan RanđelovićDepartment of Experimental Pharmacology, National Institute of Oncology, 1122 Budapest, Hungary. ivan.randel@gmail.com.
Sabine SchusterFaculty of Science, Institute of Chemistry, Eötvös Loránd University, 1117 Budapest, Hungary. sabine.schuster83@gmail.com.
Bence KapuváriDepartment of Biochemistry, National Institute of Oncology, 1122 Budapest, Hungary. zeuglodon@freemail.hu.
Gianluca FossatiPreclinical R&D, Italfarmaco SpA, 20092 Cinisello Balsamo (Milan), Italy. g.fossati@italfarmaco.com.
Christian SteinkühlerPreclinical R&D, Italfarmaco SpA, 20092 Cinisello Balsamo (Milan), Italy. c.steinkuhler@italfarmaco.com.
Gábor MezőFaculty of Science, Institute of Chemistry, Eötvös Loránd University, 1117 Budapest, Hungary. gmezo@caesar.elte.hu.
József TóváriDepartment of Experimental Pharmacology, National Institute of Oncology, 1122 Budapest, Hungary. jtovari@yahoo.com.
National Institute of Oncology · HUEötvös Loránd University · HUItalfarmaco (Italy) · IT

Funding

2019 Thematic Excellence Program TUDFO/51757/2019-ITMH2020 Marie Skłodowska-Curie Actions 642004Nemzeti Kutatási Fejlesztési és Innovációs Hivatal K 119552, NVKP_16-1-2016-0036, K116295 and KFI_16-1-2017-0439
6 · The paper itself

Abstract

Among various homing devices, gonadotropin-releasing hormone-III (GnRH-III) peptide represents a suitable targeting moiety for drug delivery systems. The anti-tumor activity of the previously developed GnRH-III-[

Indexed as

Antineoplastic AgentsDaunorubicinGonadotropin-Releasing HormonePyrrolidonecarboxylic AcidAnimalsBreast NeoplasmsCell Line, TumorCell ProliferationColorectal NeoplasmsDisease Models, AnimalFemaleGene ExpressionHumansMiceMolecular StructureReceptors, Cell SurfaceAntineoplastic AgentsDaunorubicinFSH-RF receptorGonadotropin-Releasing Hormonegonadotropin-releasing hormone-IIIPyrrolidonecarboxylic AcidReceptors, Cell SurfaceRNA, Messengeranti-metastatic activitycellular uptakedaunorubicindrug delivery systemgonadotropin releasing hormone III derivatesgonadotropin releasing hormone receptor expressionin vitro and in vivo anti-tumor activityoxime linkagepeptide drug conjugatestargeted cancer therapy

Identifiers

PMID31557968
PMCPMC6801585
OpenAlexW2975722469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.