Evidence map›Paper›PMID 31557852›Full record

ArticleNanomaterials (Basel, Switzerland)2019

Dynamic Imaging of Transferrin Receptor Molecules on Single Live Cell with Bridge Gaps-Enhanced Raman Tags.

Qinnan Zhang, Jiaosheng Li, Ping Tang, Xiaoxu Lu, Jindong Tian, Liyun Zhong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qinnan ZhangGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Photoelectric Science and Engineering, South China Normal University, Guangzhou 510006, China. zhangqinnan520@126.com.ORCID 0000-0002-3777-2667
Jiaosheng LiGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Photoelectric Science and Engineering, South China Normal University, Guangzhou 510006, China. ljsheng1989@126.com.
Ping TangGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Photoelectric Science and Engineering, South China Normal University, Guangzhou 510006, China. tangping@m.scnu.edu.cn.
Xiaoxu LuGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Photoelectric Science and Engineering, South China Normal University, Guangzhou 510006, China. hsgdzlxx@scnu.edu.cn.
Jindong TianCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China. jindt@szu.edu.cn.
Liyun ZhongGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Photoelectric Science and Engineering, South China Normal University, Guangzhou 510006, China. zhongly@scnu.edu.cn.
South China Normal University · CNShenzhen University · CN

Funding

National Natural Science Foundation of China 61575069, 61875059, 61727814, 61805086
6 · The paper itself

Abstract

A metal nanoparticles-based surface-enhanced Raman scattering (SERS) technique has been developed for biosensing and bioimaging due to its advantages in ultra-narrow line width for multiplexing, ultra-high sensitivity and excellent photostability. However, the "hotspots" effect between nanoparticles usually leads to unstable and nonuniform Raman enhancement, and this will greatly reduce the quality of SERS imaging. In this study, we employ the bridge gaps-enhanced Raman tags (BGERTs) to perform SERS imaging, in which BGERTs can not only reduce the influence of the "hotspots" effect between nanoparticles on Raman signal intensity but provide a great Raman enhancement when the Gold (Au) shell is thick enough. Based on BGERTs and its conjugation with the thiol-terminated polyethylene glycol (PEG) and transferrin, we construct a targeted Transferrin (TF)-PEG-BGERTs SERS nanoprobe and achieve the dynamic imaging of transferrin receptor (TfR) molecules on a single live cell, in which the role of transferrin-conjugated PEG-BGERT is for targeting TfR molecules located in cellular membrane surface. Importantly, this BGERTs-based SERS imaging could potentially provide a useful tool for studying the precise mechanism during the receptor-mediated nanoparticles endocytosis or cell proliferation, apoptosis, and other complicated molecular events.

Indexed as

bridge gaps-enhanced Raman tagsnanoprobeSERS-based imagingsurface-enhanced Raman scattering

Identifiers

PMID31557852
PMCPMC6835696
OpenAlexW2976071093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.