Evidence map›Paper›PMID 31557548›Full record

SynthesisNeuroscience and biobehavioral reviews2019

Multi-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: Revisiting the relevance of human coaching and elucidating interplay between multiple outcomes.

Lana Kambeitz-Ilankovic, Linda T Betz, Clara Dominke, Shalaila S Haas, Karuna Subramaniam, Melisa Fisher, Sophia Vinogradov, Nikolaos Koutsouleris, Joseph Kambeitz

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  3. European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2022
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  18. Innovations to improve outcomes and uptake of psychotherapies for mental disorders: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lana Kambeitz-IlankovicDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital of Cologne, Germany; Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany. Electronic address: lana.kambeitz-ilankovic@uk-koeln.de.
Linda T BetzDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital of Cologne, Germany.
Clara DominkeDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital of Cologne, Germany.
Shalaila S HaasIcahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, USA.
Karuna SubramaniamDepartment of Psychiatry, University of California, San Francisco, USA.
Melisa FisherDepartment of Psychiatry, Medical School, University of Minnesota, USA.
Sophia VinogradovDepartment of Psychiatry, Medical School, University of Minnesota, USA.
Nikolaos KoutsoulerisDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany.
Joseph KambeitzDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital of Cologne, Germany.

Funding

Causal Role of Medial Prefrontal Neural Activity in Self-Agency in Schizophrenia (Admin Suppl)R01MH122897 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SUBRAMANIAM, KARUNA · 2020 to 2024
$4.4M
Neural Impact of Positive Mood on Motivation and Reward Networks in SchizophreniaK01MH105615 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SUBRAMANIAM, KARUNA · 2014 to 2018
$918k
NIMH NIH HHS K01 MH105615NIMH NIH HHS R01 MH122897
6 · The paper itself

Abstract

Cognitive remediation (CR) is nowadays mainly administered in a computerized fashion, yet frequently supplemented by human guidance. The effects of CR on cognitive, functional and clinical outcomes are consistently reported, yet the response is heterogeneous. In order to resolve this heterogeneity, we employed a multi-outcome meta-analytic approach, examined effects of CR on each outcome category separately and estimated directed effects between three outcome categories. We extracted treatment effects from 67 studies that trained patients with schizophrenia (total n = 4067) using either 1) computerized CR modality alone or 2) in combination with supplementary human guidance (SHG). All three outcome domains were significantly improved by CR with small to moderate effect sizes when assessing outcomes across all studies. The comparison between CR administered with SHG revealed largest effects on the cognitive subdomains of working and verbal memory. Structural equation modeling in the single-study data suggests that cognitive gains trigger restoration of psychosocial functioning which in turn facilitates improvement in clinical symptoms.

Indexed as

Cognitive RemediationMentoringHumansSchizophreniaSchizophrenic PsychologyTreatment Outcome

Identifiers

PMID31557548
PMCPMC8942567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.