Evidence map›Paper›PMID 31557467›Full record

ArticleChest2019

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.

Priyadarshini Kachroo, Julian Hecker, Bo L Chawes, Tarunveer S Ahluwalia, Michael H Cho, Dandi Qiao, Rachel S Kelly, Su H Chu, Yamini V Virkud, Mengna Huang and 23 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Precision Medicine in Childhood Asthma: Omic Studies of Treatment Response.International journal of molecular sciences · 2020
    Review
  4. Revisiting the Population Genetics of Human Height.Journal of the Endocrine Society · 2020
    Article
  5. Pharmacogenetics of Pediatric Asthma: Current Perspectives.Pharmacogenomics and personalized medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 10 institutions in 4 countries.

Priyadarshini KachrooChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Julian HeckerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.
Bo L ChawesCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Tarunveer S AhluwaliaCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Michael H ChoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Dandi QiaoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Rachel S KellyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Su H ChuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Yamini V VirkudChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Pediatrics, Massachusetts General Hospital for Children and Harvard Medical School, Boston, MA.
Mengna HuangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Kathleen C BarnesDivision of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Colorado, CO.
Esteban G BurchardDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA.
Celeste EngDepartment of Medicine, University of California San Francisco, San Francisco, CA.
Donglei HuDepartment of Medicine, University of California San Francisco, San Francisco, CA.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA.
Michelle DayaDivision of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Colorado, CO.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI; Center for Bioinformatics, Henry Ford Health System, Detroit, MI.
Hongsheng GuiCenter for Individualized and Genomic Medicine Research, Henry Ford Health System, Detroit, MI; Department of Internal Medicine, Henry Ford Health System, Detroit, MI.
L Keoki WilliamsCenter for Individualized and Genomic Medicine Research, Henry Ford Health System, Detroit, MI; Department of Internal Medicine, Henry Ford Health System, Detroit, MI.
Erick FornoDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA.
Angel C Y MakDepartment of Medicine, University of California San Francisco, San Francisco, CA.
Lydiana AvilaDepartment of Pediatrics, Hospital Nacional de Niños, San José, Costa Rica.
Manuel E Soto-QuirosDepartment of Pediatrics, Hospital Nacional de Niños, San José, Costa Rica.
Michelle M CloutierDepartment of Pediatrics, University of Connecticut, Farmington, CT.
Edna Acosta-PérezBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Glorisa CaninoBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Klaus BønnelykkeCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Hans BisgaardCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Benjamin A RabyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Boston Children's Hospital and Harvard Medical School, Boston, MA.
Christoph LangeDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jessica A Lasky-SuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Electronic address: rejas@channing.harvard.edu.
National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium
Brigham and Women's Hospital · USHenry Ford Health System · USUniversity of Colorado Anschutz Medical Campus · USHarvard University · USUniversity of California, San Francisco · USUniversity of Copenhagen · DKUniversity of Pittsburgh · USUniversity of Puerto Rico System · PRHospital Nacional de Niños · CRUniversity of Connecticut · US

Funding

New Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1M
The Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6M
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BARABASI, ALBERT-LASZLO · 2016 to 2020
$12.6M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Center for Hemoglobin Research in Minorities (CHaRM)P50HL118006 · NHLBI · HOWARD UNIVERSITY · PI NEKHAI, SERGEI · 2013 to 2017
$7.0M
Integrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2012 to 2016
$6.4M
Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
SF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2M
NHLBI NIH HHS K01 HL004370NHLBI NIH HHS K01 HL129039NHLBI NIH HHS K01 HL146980NHLBI NIH HHS P01 HL132825NHLBI NIH HHS P50 HL118006NHLBI NIH HHS R01 HL066289NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117191NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL138737NHLBI NIH HHS R01 HL141826NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R37 HL066289NHLBI NIH HHS T32 HL139439NIAID NIH HHS K23 AI130408NIAID NIH HHS R01 AI079139NIAID NIH HHS R01 AI132476NIA NIH HHS K01 AG059898NIDDK NIH HHS R01 DK113003NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS R01 GM075316NIGMS NIH HHS RL5 GM118984NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
6 · The paper itself

Abstract

backgroundAsthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function in individuals with a diagnosis of asthma.

methodsWGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based Genetic Epidemiology of Asthma in Costa Rica study. Asthma affection status was defined through a physician's diagnosis of asthma, and most participants with asthma also had airway hyperresponsiveness (AHR) to methacholine. Family-based association tests for single variants were performed to assess the associations with lung function phenotypes.

resultsA genome-wide significant association was identified between baseline FEV

conclusionsThese findings suggest that using specific asthma characteristics, such as AHR, can help identify more genetically homogeneous asthma subgroups with genotype-phenotype associations that may not be observed in all children with asthma. CRISPLD2 also may be important for baseline lung function in individuals with asthma who also may have AHR.

Indexed as

Whole Genome SequencingAdolescentAdultAsthmaCell Adhesion MoleculesChildChild, PreschoolCosta RicaFemaleForced Expiratory VolumeHumansInterferon Regulatory FactorsMaleMiddle AgedRespiratory Physiological PhenomenaVital CapacityCell Adhesion MoleculesCRISPLD2 protein, humanInterferon Regulatory Factorsairway hyperresponsivenessasthmalung functionwhole genome sequencing

Identifiers

PMID31557467
PMCPMC6904857
OpenAlexW2976705022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.