Evidence map›Paper›PMID 31557453›Full record

ArticleCell systems2019

Simple Rules Determine Distinct Patterns of Branching Morphogenesis.

Wei Yu, Wallace F Marshall, Ross J Metzger, Paul R Brakeman, Leonardo Morsut, Wendell Lim, Keith E Mostov

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell systems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei YuDepartments of Anatomy, University of California San Francisco, San Francisco, CA, USA; Cell and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Wallace F MarshallCenter for Cellular Construction, University of California San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Ross J MetzgerDepartments of Anatomy, University of California San Francisco, San Francisco, CA, USA; Department of Pediatrics (Cardiology), Stanford University School of Medicine, Stanford, CA, USA.
Paul R BrakemanDepartment of Pediatrics (Nephrology), University of California San Francisco, San Francisco, CA, USA.
Leonardo MorsutCell and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Wendell LimCell and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA.
Keith E MostovDepartments of Anatomy, University of California San Francisco, San Francisco, CA, USA; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA. Electronic address: keith.mostov@ucsf.edu.

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2008 to 2022
$13.4M
Origins of Cell GeometryR35GM130327 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wallace Marshall · 2019 to 2026
$5.3M
Recovery from acute kidney injuryR01DK074398 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSTOV, KEITH E · 2007 to 2015
$3.0M
Control of Epithelial PolarityR01DK091530 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSTOV, KEITH E · 2011 to 2015
$1.7M
Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact R00EB021030 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MORSUT, LEONARDO · 2017 to 2019
$716k
Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact SignalsK99EB021030 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MORSUT, LEONARDO · 2015 to 2016
$195k
NIBIB NIH HHS K99 EB021030NIBIB NIH HHS R00 EB021030NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK074398NIDDK NIH HHS R01 DK091530
6 · The paper itself

Abstract

Many metazoan organs are comprised of branching trees of epithelial tubes; how patterning occurs in these trees is a fundamental problem of development. Commonly, branch tips fill the volume of the organ approximately uniformly, e.g., in mammalian lung, airway branch tips are dispersed roughly uniformly throughout the volume of the lung. In contrast, in the developing metanephric kidney, the tips of the ureteric bud tree are located close to the outer surface of the kidney rather than filling the kidney. Here, we describe a simple alteration in the branching rules that accounts for the difference between the kidney pattern that leads to tips near the organ surface versus previously known patterns that lead to the branch tips being dispersed throughout the organ. We further use a simple toy model to deduce from first principles how this rule change accounts for the differences in the two types of trees.

Indexed as

AnimalsBody PatterningEmbryo, MammalianEpitheliumGene Expression Regulation, DevelopmentalHumansKidneyLungModels, BiologicalMorphogenesis

Identifiers

PMID31557453
PMCPMC7577355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.