ArticleMolecular plant pathology2019
Small RNA inhibits infection by downy mildew pathogen Hyaloperonospora arabidopsidis.
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Control of Phytophthora capsici, which causes root and stem rot, using encapsulated oligonucleotide DNA.Scientific reports · 2026Article
- RNAi Strategies Against Downy Mildews: Insights Into dsRNA Uptake and Silencing.Molecular plant pathology · 2025Article
- Sorbitol induces flavonoid accumulation as a secondary signal via the nanoencapsulated SPc/lncRNA809-MmNAC17 module against Alternaria alternata in Malus micromalus.Molecular horticulture · 2025Article
- Integrative transcriptome and WGCNA analysis reveal key genes mainly in response toFrontiers in plant science · 2025Article
- Loss of Sterol Biosynthesis in Economically Important Plant Pests and Pathogens: A Review of a Potential Target for Pest Control.Biomolecules · 2024Review
- Development of an RNA Nanostructure for EffectiveJournal of fungi (Basel, Switzerland) · 2024Article
- Spray-induced gene silencing to identify powdery mildew gene targets and processes for powdery mildew control.Molecular plant pathology · 2023Article
- Biological function research of Fusarium oxysporum f. sp. cubense inducible banana long noncoding RNA Malnc2310 in Arabidopsis.Plant molecular biology · 2023Article
- RNA Interference Past and Future Applications in Plants.International journal of molecular sciences · 2023Review
- Genome-wide identification and validation of tomato-encoded sRNA as the cross-species antifungal factors targeting the virulence genes ofFrontiers in plant science · 2023Article
- A comparison of transporter gene expression in three species of Peronospora plant pathogens during host infection.PloS one · 2023Article
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- Signal and regulatory mechanisms involved in spore development ofFrontiers in microbiology · 2022Review
- Small RNA-based plant protection against diseases.Frontiers in plant science · 2022Review
- An Arabidopsis downy mildew non-RxLR effector suppresses induced plant cell death to promote biotroph infection.Journal of experimental botany · 2021Article
- Host-derived extracellular vesicles for antimicrobial defense.microLife · 2021Article
- Extracellular Vesicles: Emerging Players in Plant Defense Against Pathogens.Frontiers in plant science · 2021Review
- High-Throughput Sequencing Reveals the Regulatory Networks of Transcriptome and Small RNAs During the Defense AgainstFrontiers in plant science · 2021Article
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Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene silencing exists in eukaryotic organisms as a conserved regulation of the gene expression mechanism. In general, small RNAs (sRNAs) are produced within the eukaryotic cells and incorporated into an RNA-induced silencing complex (RISC) within cells. However, exogenous sRNAs, once delivered into cells, can also silence target genes via the same RISC. Here, we explored this concept by targeting the Cellulose synthase A3 (CesA3) gene of Hyaloperonospora arabidopsidis (Hpa), the downy mildew pathogen of Arabidopsis thaliana. Hpa spore suspensions were mixed with sense or antisense sRNAs and inoculated onto susceptible Arabidopsis seedlings. While sense sRNAs had no obvious effect on Hpa pathogenicity, antisense sRNAs inhibited spore germination and hence infection. Such inhibition of infection was not race-specific, but dependent on the length and capping of sRNAs. Inhibition of infection by double stranded sRNA was more efficient than that observed with antisense sRNA. Thus, exogenous sRNA targeting conserved CesA3 could suppress Hpa infection in Arabidopsis, indicating the potential of this simple and efficient sRNA-based approach for deciphering gene functions in obligate biotrophic pathogens as well as for R-gene independent control of diseases in plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.