ArticleJournal of cellular and molecular medicine2019
Aberrantly expressed long non-coding RNAs in air pollution-induced congenital defects.
Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Gut microbiota and tuberculosis.iMeta · 2025Review
- Associations between PMFrontiers in public health · 2024Article
- Molecular mechanisms of environmental exposures and human disease.Nature reviews. Genetics · 2023Review
- Association between air pollutants and birth defects in Xiamen, China.Frontiers in pediatrics · 2023Article
- Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs.Biomolecules · 2022Review
- Associations between air pollution exposure and birth defects: a time series analysis.Environmental geochemistry and health · 2021Article
- lncRNA-disease association prediction based on latent factor model and projection.Scientific reports · 2021Article
- Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis.Environmental science and pollution research international · 2021Review
- Role of non-coding-RNAs in response to environmental stressors and consequences on human health.Redox biology · 2020Review
- LncRNA-mRNA expression profiles and functional networks in osteoclast differentiation.Journal of cellular and molecular medicine · 2020Article
- Embryonic gene expression altered by maternal exposure to air pollution in rats.Environmental science and pollution research international · 2020Article
- Deciphering the Code between Air Pollution and Disease: The Effect of Particulate Matter on Cancer Hallmarks.International journal of molecular sciences · 2019Review
- Aberrantly expressed long non-coding RNAs in air pollution-induced congenital defects.Journal of cellular and molecular medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Air pollution has been a serious public health issue over the past few decades particularly in developing countries. Air pollution exposure during pregnancy poses potential threat to offspring as the deleterious substances might pass through placenta to alter foetal development. A growing number of studies have demonstrated that long non-coding RNAs (lncRNAs) participate in the development of many diseases, including congenital defects. Here, we used RNA sequencing to identify differentially expressed lncRNAs in air pollution-exposed rat embryos compared with control group. Our data suggested that 554 lncRNAs (216 up-regulated and 338 down-regulated) were significantly differentially expressed in the air pollution-exposed embryos. Moreover, potential cellular functions of these deregulated lncRNAs were predicted via KEGG signal pathway/GO enrichment analyses, which suggested the possible involvements of neurological process, sensory perception of smell and the G-protein signalling pathway. Furthermore, potential functional network of deregulated lncRNAs and their correlated mRNAs in the development of congenital spinal abnormality was established. Our data suggested that lncRNAs may play a vital role in the pathophysiology of air pollution-exposed congenital spinal malformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.