Evidence map›Paper›PMID 31556721›Full record

ArticleFuture medicinal chemistry2019

Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria.

Marilia Nn Lima, Bruno J Neves, Gustavo C Cassiano, Marcelo N Gomes, Kaira Cp Tomaz, Leticia T Ferreira, Tatyana A Tavella, Juliana Calit, Daniel Y Bargieri, Eugene N Muratov and 2 more

Abstract read
In one paragraph

Article in Future medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery.Advances in experimental medicine and biology · 2021
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marilia Nn LimaLabMol, Laboratory for Molecular Modeling & Drug Design, Faculty of Pharmacy, Federal University of Goiás, Rua 240, Qd. 87, Goiânia, GO 74605-170, Brazil.
Bruno J NevesLabMol, Laboratory for Molecular Modeling & Drug Design, Faculty of Pharmacy, Federal University of Goiás, Rua 240, Qd. 87, Goiânia, GO 74605-170, Brazil.ORCID 0000-0002-1309-8743
Gustavo C CassianoLaboratory of Tropical Diseases, Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology & Immunology, Institute of Biology, UNICAMP, Campinas, SP 13083-970, Brazil.
Marcelo N GomesLabMol, Laboratory for Molecular Modeling & Drug Design, Faculty of Pharmacy, Federal University of Goiás, Rua 240, Qd. 87, Goiânia, GO 74605-170, Brazil.
Kaira Cp TomazLaboratory of Tropical Diseases, Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology & Immunology, Institute of Biology, UNICAMP, Campinas, SP 13083-970, Brazil.
Leticia T FerreiraLaboratory of Tropical Diseases, Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology & Immunology, Institute of Biology, UNICAMP, Campinas, SP 13083-970, Brazil.
Tatyana A TavellaLaboratory of Tropical Diseases, Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology & Immunology, Institute of Biology, UNICAMP, Campinas, SP 13083-970, Brazil.
Juliana CalitDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Daniel Y BargieriDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Eugene N MuratovLaboratory for Molecular Modeling, Division of Chemical Biology & Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27955-7568, USA.
Fabio Tm CostaLaboratory of Tropical Diseases, Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology & Immunology, Institute of Biology, UNICAMP, Campinas, SP 13083-970, Brazil.
Carolina Horta AndradeLabMol, Laboratory for Molecular Modeling & Drug Design, Faculty of Pharmacy, Federal University of Goiás, Rua 240, Qd. 87, Goiânia, GO 74605-170, Brazil.ORCID 0000-0003-0101-1492

Funding

Drug Repurposing for Cancer Therapy: From Man to Molecules to ManU01CA207160 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TROPSHA, ALEXANDER · 2016 to 2018
$1.2M
Integrating cheminformatics and molecular simulations for virtual drug screeningR01GM114015 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOKHOLYAN, NIKOLAY · 2016 to 2019
$1.1M
NCI NIH HHS U01 CA207160NIGMS NIH HHS R01 GM114015
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Computer-Aided DesignDrug DesignAntimalarialsChalconesHumansMalariaAntimalarialsChalconesdrug designexperimental validationmolecular dockingpharmacophorePlasmodium falciparumvirtual screening

Identifiers

PMID31556721
PMCPMC7333642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.