Evidence map›Paper›PMID 31556669›Full record

Trial reportJournal of consulting and clinical psychology2019

Mindfulness-oriented recovery enhancement reduces opioid misuse risk via analgesic and positive psychological mechanisms: A randomized controlled trial.

Eric L Garland, Adam W Hanley, Michael R Riquino, Sarah E Reese, Anne K Baker, Karen Salas, Brooke P Yack, Carter E Bedford, Myranda A Bryan, Rachel Atchley and 3 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of consulting and clinical psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 5 pooled it
22.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 5 syntheses or guidelines pooled it, 159 citations in OpenAlex.

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  4. Mindfulness-based interventions for substance use disorders.The Cochrane database of systematic reviews · 2021
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  20. Chronic Pain and Opioids in the Elderly: Treating the Brain, Not Just the Body.International journal of environmental research and public health · 2026
    Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Eric L GarlandCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Adam W HanleyCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Michael R RiquinoCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Sarah E ReeseCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Anne K BakerCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Karen SalasCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Brooke P YackCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Carter E BedfordCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Myranda A BryanCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Rachel AtchleyCenter on Mindfulness and Integrative Health Intervention Development and College of Social Work, University of Utah.
Yoshio NakamuraCenter on Mindfulness and Integrative Health Intervention Development and Department of Anesthesiology, University of Utah.
Brett FroeligerDepartment of Neuroscience, Medical University of South Carolina.
Matthew O HowardSchool of Social Work, University of North Carolina at Chapel Hill.
Medical University of South Carolina · USUniversity of North Carolina at Chapel Hill · US

Funding

Targeting Hedonic Dysregulation to Address Chronic Pain and Opioid Misuse in Primary Care.R01DA042033 · NIDA · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE · 2016 to 2020
$2.8M
Effects of Mindfulness-Oriented Intervention on Endogenous Opioid Mechanisms of Hedonic Regulation in Chronic Pain.R61AT009296 · NCCIH · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE, ZUBIETA, JON-KAR · 2016 to 2017
$831k
Fahs Beck Fund for Research and ExperimentationNational Center for Complementary and Alternative MedicineNCCIH NIH HHS R61 AT009296NIDA NIH HHS R01 DA042033Stephanie Loker Hurst
6 · The paper itself

Abstract

objectiveDespite the heightened urgency of the current prescription opioid crisis, few psychotherapies have been evaluated for chronic pain patients receiving long-term opioid analgesics. Current psychological pain treatments focus primarily on ameliorating negative affective processes, yet basic science suggests that risk for opioid misuse is linked with a dearth of positive affect. Interventions that modulate positive psychological processes may produce therapeutic benefits among patients with opioid-treated chronic pain. The aim of this study was to conduct a theory-driven mechanistic analysis of proximal outcome data from a Stage 2 randomized controlled trial of Mindfulness-Oriented Recovery Enhancement (MORE), an integrative intervention designed to promote positive psychological health.

methodPatients with opioid-treated chronic pain (N = 95; age = 56.8 ± 11.7; 66% female) were randomized to 8 weeks of therapist-led MORE or support group (SG) interventions. A latent positive psychological health variable comprised of positive affect, meaning in life, and self-transcendence measures was examined as a mediator of the effect of MORE on changes in pain severity at posttreatment and opioid misuse risk by 3-month follow-up.

resultsParticipants in MORE reported significantly greater reductions in pain severity by posttreatment (p = .03) and opioid misuse risk by 3-month follow-up (p = .03) and significantly greater increases in positive psychological health (p < .001) than SG participants. Increases in positive psychological health mediated the effect of MORE on pain severity by posttreatment (p = .048), which in turn predicted decreases in opioid misuse risk by follow-up (p = .02).

conclusionsTargeting positive psychological mechanisms via MORE and other psychological interventions may reduce opioid misuse risk among chronic pain patients receiving long-term opioid therapy. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Indexed as

MindfulnessSelf-Help GroupsAdultAffectAgedAnalgesiaAnalgesics, OpioidChronic PainFemaleHumansMaleMiddle AgedOpioid-Related DisordersPsychotherapeutic ProcessesTreatment OutcomeAnalgesics, Opioid

Identifiers

PMID31556669
PMCPMC6764586
OpenAlexW2976431867

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.